Institute of Virology, Philipps-University Marburg, Hans-Meerwein-Strasse 2, 35043, Marburg, Germany.
FEBS Lett. 2024 May;598(10):1299-1300. doi: 10.1002/1873-3468.14819. Epub 2024 Feb 13.
Intracellular pathogens rely on host metabolic networks for multiplication. Enveloped viruses need lipids for formation of the viral envelope and positive sense RNA viruses that replicate in membranous inclusions require lipids for formation of the replication compartments. In addition, all intracellular pathogens need energy for their replicative cycle. As triglycerides in lipid droplets are the main energy storage unit of cells and major source of membrane lipids, it is not surprising that viruses have evolved various strategies to exploit different aspects of lipid droplet biology.
细胞内病原体依赖于宿主代谢网络进行繁殖。包膜病毒需要脂质来形成病毒包膜，而在膜包涵体内复制的正链 RNA 病毒则需要脂质来形成复制隔间。此外，所有细胞内病原体的复制周期都需要能量。由于脂滴中的甘油三酯是细胞的主要能量储存单元和膜脂质的主要来源，因此病毒进化出各种策略来利用脂滴生物学的不同方面也就不足为奇了。
