Johnson R M
Blood Cells. 1985;11(2):317-21, 323-4.
The effect of pH on erythrocyte deformability was determined in the ektacytometer. In isotonic solutions, cell deformability was essentially unaltered at pH values from 6.44 to 7.7, despite the known cell volume changes that occur over this pH range. Analysis by osmotic scan ektacytometry showed that erythrocyte deformability is homeostatically maintained constant during acidosis and alkalosis because of a balance between the countervailing effects of changes in intracellular viscosity and in the surface to volume ratio. This balance is perturbed in the sickle erythrocyte, so that acidosis improves deformability.
在激光衍射血细胞变形性测定仪中测定了pH对红细胞变形性的影响。在等渗溶液中，尽管已知在此pH范围内细胞体积会发生变化，但在pH值为6.44至7.7时，细胞变形性基本未改变。渗透扫描激光衍射血细胞变形性分析表明，由于细胞内粘度和表面积与体积比变化的抵消作用之间的平衡，红细胞变形性在酸中毒和碱中毒期间通过稳态维持恒定。这种平衡在镰状红细胞中受到干扰，因此酸中毒会改善变形性。
