Beiguelman B, Pinto W, El-Guindy M M, Krieger H
Bull World Health Organ. 1974;51(5):467-71.
The level of dapsone in the blood 4 and 6 h after the ingestion of the 7th daily dose of 100 mg of the drug was investigated in 36 adult males with leprosy who had normal renal function and were free of diarrhoea and emesis. The bimodal distribution of the dapsone levels at 6 h was shown by multiple regression analysis to be due to a negative correlation between this trait and the haematocrit value. Among the patients with high dapsone blood levels, 81.8% presented haematocrit values under 36%, whereas only 20% of those with low levels showed low haematocrit values. Partial regression coefficients, calculated for the dapsone level on the age, weight of the patient, estimated number of years since the onset of leprosy, number of years under sulfone treatment, and blood levels of haemoglobin, albumin, and globulins, did not show statistical significance.
对36名肾功能正常、无腹泻和呕吐症状的成年男性麻风患者，在每日服用第7剂100毫克氨苯砜4小时和6小时后，检测其血液中氨苯砜的水平。多元回归分析表明，6小时时氨苯砜水平的双峰分布是由于该性状与血细胞比容值呈负相关。在氨苯砜血药浓度高的患者中，81.8%的患者血细胞比容值低于36%，而在血药浓度低的患者中，只有20%的患者血细胞比容值低。计算氨苯砜水平与患者年龄、体重、估计麻风发病年限、砜类治疗年限以及血红蛋白、白蛋白和球蛋白血药浓度之间的偏回归系数，未显示出统计学意义。
