Choi Ha-Neul, Kim Jung-In
Department of Food and Nutrition, Changwon National University, Changwon 51140, Korea.
Institute of Digital Anti-Aging Healthcare, Inje University, Gimhae 50834, Korea.
Nutr Res Pract. 2024 Feb;18(1):88-97. doi: 10.4162/nrp.2024.18.1.88. Epub 2024 Jan 25.
BACKGROUND/OBJECTIVES: Mitigating insulin resistance and hyperglycemia is associated with a decreased risk of diabetic complications. The effect of Daraesoon (shoot of hardy kiwi, ) on hyperglycemia was investigated using a type 2 diabetes animal model.
MATERIALS/METHODS: Seven-week-old db/db mice were fed either an AIN-93G diet or a diet containing 0.4% of a 70% ethanol extract of Daraesoon, whereas db/+ mice were fed the AIN-93G diet for 7 weeks.
Consumption of Daraesoon significantly reduced serum glucose and blood glycated hemoglobin levels, along with homeostasis model assessment for insulin resistance in db/db mice. Conversely, Daraesoon elevated the serum adiponectin levels compared to the db/db control group. Furthermore, Daraesoon significantly decreased both serum and hepatic triglyceride levels, as well as serum total cholesterol levels. Additionally, consumption of Daraesoon resulted in decreased hepatic tumor necrosis factor-α and monocyte chemoattractant protein-1 expression.
These results suggest that hypoglycemic effect of Daraesoon is mediated through the improvement of insulin resistance and the downregulation of pro-inflammatory cytokine expression in db/db mice.
背景/目的：减轻胰岛素抵抗和高血糖与降低糖尿病并发症风险相关。使用2型糖尿病动物模型研究了软枣猕猴桃嫩梢（Daraesoon）对高血糖的影响。
材料/方法：给7周龄的db/db小鼠喂食AIN-93G饮食或含有0.4%软枣猕猴桃70%乙醇提取物的饮食，而db/+小鼠喂食AIN-93G饮食7周。
食用软枣猕猴桃显著降低了db/db小鼠的血清葡萄糖和糖化血红蛋白水平，以及胰岛素抵抗的稳态模型评估值。相反，与db/db对照组相比，软枣猕猴桃提高了血清脂联素水平。此外，软枣猕猴桃显著降低了血清和肝脏甘油三酯水平以及血清总胆固醇水平。此外，食用软枣猕猴桃导致肝脏肿瘤坏死因子-α和单核细胞趋化蛋白-1表达降低。
这些结果表明，软枣猕猴桃的降血糖作用是通过改善db/db小鼠的胰岛素抵抗和下调促炎细胞因子表达来介导的。
