Vohra Shweta, Pradhan Akshyaya, Sethi Rishi, Bhandari Monika
Department of Cardiology, King George's Medical University, Lucknow, Uttar Pradesh, India.
Int J Angiol. 2021 Sep 21;33(1):57-61. doi: 10.1055/s-0041-1723945. eCollection 2024 Feb.
Lithium is considered a gold standard drug for the management of bipolar disorder and is a widely used mood-stabilizing drug in psychiatry practice. However, its side effects are of important concern. The narrow therapeutic index of lithium predispose to its toxicity/side effects, but various case reports and research has shown that adverse drug reactions can occur even in the therapeutic range. We present the case of a 56-year-old woman with no history of cardiac illness presenting with tachycardia-bradycardia syndrome along with moderate pulmonary hypertension. Patients recovered to sinus rhythm after withholding lithium therapy for 1 week while her mean pulmonary artery pressure remained the same at day 10 of drug withdrawal.
锂被认为是治疗双相情感障碍的金标准药物，是精神病学实践中广泛使用的情绪稳定药物。然而，其副作用令人高度关注。锂的治疗指数狭窄，易导致毒性/副作用，但各种病例报告和研究表明，即使在治疗范围内也可能发生药物不良反应。我们报告一例56岁女性患者，既往无心脏病史，出现心动过速-心动过缓综合征并伴有中度肺动脉高压。停用锂治疗1周后患者恢复窦性心律，停药第10天时其平均肺动脉压保持不变。
