Department of Urology, T.C Ministry of Health, Karabuk Training and Research Hospital, Karabuk, Turkey.
Prostate. 2024 May;84(6):599-604. doi: 10.1002/pros.24677. Epub 2024 Feb 14.
To compare the effect of biopsy needle disinfection with 10% formalin solution alone and with povidone-iodine rectal cleaning on preventing infectious complications requiring hospitalization.
The data of 902 patients who underwent prostate biopsy by transrectal route were retrospectively analyzed. Inclusion criteria were prophylactic antibiotic use and negative urine culture before the biopsy. Three groups occurred according to the methods used during the biopsy procedure. In Group 1, 501 patients, biopsy needle disinfection was made using 10% formalin solution during the biopsy procedure. Group 2, 164 patients, applied only prophylactic antibiotics. Group 3, 237 patients, applied both 10% formalin disinfection of the biopsy needle and prebiopsy povidone-iodine rectal cleansing. Hospitalized patients because of infectious complications a month after the biopsy were our outcome measures.
Hospitalization rates because of biopsy-related infectious complications, according to Groups 1, 2, and 3, were 2.7%, 8.5%, and 0%, respectively. The best results were observed in Group 3 and the worst in Group 2.
The two nonantibiotic strategies, biopsy needle disinfection with formalin solution and rectal cleaning with povidone-iodine, look more effective when applied together. However, further prospective studies are required to confirm our analysis.
比较单独使用 10%福尔马林溶液和使用聚维酮碘直肠清洁对预防需要住院治疗的感染性并发症的效果。
回顾性分析了 902 例经直肠途径行前列腺活检的患者数据。纳入标准为活检前预防性使用抗生素且尿液培养阴性。根据活检过程中使用的方法将患者分为三组。第 1 组 501 例，在活检过程中使用 10%福尔马林溶液对活检针进行消毒。第 2 组 164 例，仅使用预防性抗生素。第 3 组 237 例，同时使用 10%福尔马林溶液消毒活检针和术前聚维酮碘直肠清洁。我们的结局指标为活检后 1 个月因感染性并发症住院的患者。
根据第 1、2 和 3 组，因活检相关感染性并发症而住院的发生率分别为 2.7%、8.5%和 0%。第 3 组的结果最好，第 2 组最差。
当联合应用福尔马林溶液消毒活检针和聚维酮碘直肠清洁这两种非抗生素策略时，效果似乎更好。然而，需要进一步的前瞻性研究来证实我们的分析。
