Fattahi Mehdi, Maghsudlu Mohadese, Razipour Masoumeh, Movahedpour Ahmad, Ghadami Mohsen, Alizadeh Mehdi, Khatami Seyyed Hossein, Taheri-Anganeh Mortaza, Ghasemi Ehsan, Ghasemi Hassan, Aiiashi Saleh, Ghadami Elham
Institute of Research and Development, Duy Tan University, Da Nang, Vietnam; School of Engineering & Technology, Duy Tan University, Da Nang, Vietnam.
Department of Medical Genetics, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Clin Chim Acta. 2024 Mar 15;556:117829. doi: 10.1016/j.cca.2024.117829. Epub 2024 Feb 13.
Glioblastoma (GBM) is the most common type of malignant brain tumor.The discovery of microRNAs and their unique properties have made them suitable tools as biomarkers for cancer diagnosis, prognosis, and evaluation of therapeutic response using different types of nanomaterials as sensitive and specific biosensors. In this review, we discuss microRNA-based electrochemical biosensing systems and the use of nanoparticles in the evolving development of microRNA-based biosensors in glioblastoma.
胶质母细胞瘤（GBM）是最常见的恶性脑肿瘤类型。微小RNA的发现及其独特性质使其成为适用于癌症诊断、预后评估以及使用不同类型纳米材料作为灵敏且特异的生物传感器来评估治疗反应的生物标志物工具。在本综述中，我们讨论基于微小RNA的电化学生物传感系统以及纳米颗粒在胶质母细胞瘤中基于微小RNA的生物传感器不断发展过程中的应用。
