Dorosti Nafiseh, Khatami Seyyed Hossein, Karami Neda, Taheri-Anganeh Mortaza, Mahhengam Negah, Rajabvand Narges, Asadi Peyman, Movahedpour Ahmad, Ghasemi Hassan
Department of Medical Nanotechnology, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Department of Clinical Biochemistry, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Clin Chim Acta. 2023 Feb 15;541:117245. doi: 10.1016/j.cca.2023.117245. Epub 2023 Feb 6.
Gastrointestinal (GI) cancers are one of the most common causes of cancer-related mortality. The discovery of microRNAs (miRs) and their unique role in cancer and other diseases has prompted the development of highly sensitive molecular diagnostic tools using nanomaterials as sensitive and specific biosensors. Among these, electrochemical biosensors, which are based on a simple and inexpensive design, make them desirable in clinical applications as well as a mass-produced point-of-care device. We review miR-based electrochemical biosensors in GI cancer and examine the use of nanoparticles in the evolving development of miR-based biosensors. Among these, a number of approaches including redox labeled probes, catalysts, redox intercalating agents and free redox indicators are highlighted for use in electrochemical biosensor technology.
胃肠道（GI）癌症是癌症相关死亡的最常见原因之一。微小RNA（miRs）的发现及其在癌症和其他疾病中的独特作用促使人们开发出以纳米材料作为灵敏且特异的生物传感器的高灵敏度分子诊断工具。其中，基于简单且低成本设计的电化学生物传感器，使其在临床应用以及大规模生产的即时检测设备中具有吸引力。我们综述了用于胃肠道癌症的基于miR的电化学生物传感器，并研究了纳米颗粒在基于miR的生物传感器不断发展的过程中的应用。其中，包括氧化还原标记探针、催化剂、氧化还原嵌入剂和游离氧化还原指示剂在内的多种方法被重点介绍用于电化学生物传感器技术。
