Wellcome Centre for Integrative Neuroimaging (WIN), Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK
Wellcome Centre for Integrative Neuroimaging (WIN), Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.
BMJ Open. 2024 Feb 13;14(2):e077442. doi: 10.1136/bmjopen-2023-077442.
There is growing evidence that sleep is disrupted after stroke, with worse sleep relating to poorer motor outcomes. It is also widely acknowledged that consolidation of motor learning, a critical component of poststroke recovery, is sleep-dependent. However, whether the relationship between disrupted sleep and poor outcomes after stroke is related to direct interference of sleep-dependent motor consolidation processes, is currently unknown. Therefore, the aim of the present study is to understand whether measures of motor consolidation mediate the relationship between sleep and clinical motor outcomes post stroke.
We will conduct a longitudinal observational study of up to 150 participants diagnosed with stroke affecting the upper limb. Participants will be recruited and assessed within 7 days of their stroke and followed up at approximately 1 and 6 months. The primary objective of the study is to determine whether sleep in the subacute phase of recovery explains the variability in upper limb motor outcomes after stroke (over and above predicted recovery potential from the Predict Recovery Potential algorithm) and whether this relationship is dependent on consolidation of motor learning. We will also test whether motor consolidation mediates the relationship between sleep and whole-body clinical motor outcomes, whether motor consolidation is associated with specific electrophysiological sleep signals and sleep alterations during subacute recovery.
This trial has received both Health Research Authority, Health and Care Research Wales and National Research Ethics Service approval (IRAS: 304135; REC: 22/LO/0353). The results of this trial will help to enhance our understanding of the role of sleep in recovery of motor function after stroke and will be disseminated via presentations at scientific conferences, peer-reviewed publication, public engagement events, stakeholder organisations and other forms of media where appropriate.
ClinicalTrials.gov: NCT05746260, registered on 27 February 2023.
越来越多的证据表明，中风后睡眠会受到干扰，睡眠质量越差，运动功能恢复越差。人们普遍认为，运动学习的巩固是中风后恢复的关键组成部分，而这一过程依赖于睡眠。然而，中风后睡眠中断与不良结局之间的关系是否与睡眠依赖性运动巩固过程的直接干扰有关，目前尚不清楚。因此，本研究旨在了解运动巩固的测量指标是否可以介导中风后睡眠与临床运动结局之间的关系。
我们将对多达 150 名被诊断为影响上肢的中风患者进行一项纵向观察性研究。参与者将在中风后 7 天内被招募和评估，并在大约 1 个月和 6 个月时进行随访。研究的主要目的是确定恢复期的睡眠是否可以解释中风后上肢运动结局的变异性（超过预测恢复潜力算法所预测的恢复潜力），以及这种关系是否依赖于运动学习的巩固。我们还将测试运动巩固是否可以介导睡眠与全身临床运动结局之间的关系，运动巩固是否与特定的电生理睡眠信号以及亚急性恢复期的睡眠改变有关。
这项试验已经获得了英国健康研究管理局、威尔士健康与护理研究管理局和国家研究伦理服务局的批准（IRAS：304135；REC：22/LO/0353）。这项试验的结果将有助于我们更好地了解睡眠在中风后运动功能恢复中的作用，并将通过在科学会议上的演讲、同行评议的出版物、公众参与活动、利益相关者组织和其他适当的媒体形式进行传播。
ClinicalTrials.gov：NCT05746260，于 2023 年 2 月 27 日注册。
