Kong Yan-Chen, Wang Dan-Ling, Zhang Jing-Jing, Yang Yu-Xin, Xu Cong-Hui, Javed Rida, Zhao Hongbin, Ye Daixin, Zhao Wei
Institute of Nanochemistry and Nanobiology, School of Environmental and Chemical Engineering, Shanghai University, Shanghai, 200444, China.
Institute for Sustainable Energy/College of Sciences, Shanghai University, Shanghai, 200444, China.
Anal Chim Acta. 2024 Mar 22;1295:342322. doi: 10.1016/j.aca.2024.342322. Epub 2024 Feb 1.
The advancement of highly sensitive electrochemiluminescence (ECL) biosensors has garnered escalating interest over time. Owing to the distinctive physicochemical attributes, the signal amplification strategy facilitated by functional nanomaterials has achieved notable milestones. Single-atom catalysts (SACs), featuring atomically dispersed metal active sites, have garnered significant attention. SACs offer unprecedented control over active sites and surface structures at the atomic level. However, to fully harness their potential, ongoing efforts focus on strategies to enhance the catalytic performance of SACs, profoundly influencing both the sensitivity and selectivity of SACs-based sensing platforms.
In this study, we focused on the synthesis and application of Fe-Co-PNC dual-atom catalysts (DACs) with the incorporation of phosphorus, aiming to enhance catalytic efficiency, particularly in the context of the oxygen reduction reaction (ORR) correlated cathodic luminol ECL. The synergistic effects arising from the combination of Fe and Co in DACs were explored by ECL emission. Comparative studies with Fe-PNC SACs highlighted the superior catalytic performance of Fe-Co-PNC DACs. The ECL sensing platform exhibited excellent sensitivity, which provided a fast detection of Trolox with a wide linear range (0.1 μM-1.0 mM) and a low detection limit (LOD) of 0.03 μM. The platform demonstrated remarkable reproducibility and long-term stability, showcasing its potential for practical biosensing applications.
This study introduced the novel concept of Fe-Co-PNC DACs. The demonstrated synergistic effects and enhanced catalytic efficiency of DACs offer new avenues for the rational design of advanced catalysts. The successful application in the sensitive detection of Trolox emphasizes their potential significance in biosensing. It not only expands our understanding of SACs but also opens doors for the development of efficient and stable catalysts with broader applications.
随着时间的推移，高灵敏度电化学发光（ECL）生物传感器的发展引起了越来越多的关注。由于独特的物理化学特性，功能纳米材料促进的信号放大策略取得了显著进展。具有原子分散金属活性位点的单原子催化剂（SAC）受到了广泛关注。SAC在原子水平上对活性位点和表面结构提供了前所未有的控制。然而，为了充分发挥其潜力，目前的努力集中在提高SAC催化性能的策略上，这对基于SAC的传感平台的灵敏度和选择性都有深远影响。
在本研究中，我们专注于含磷的Fe-Co-PNC双原子催化剂（DAC）的合成与应用，旨在提高催化效率，特别是在与氧还原反应（ORR）相关的阴极鲁米诺ECL的背景下。通过ECL发射探索了DAC中Fe和Co组合产生的协同效应。与Fe-PNC SAC的比较研究突出了Fe-Co-PNC DAC的优异催化性能。ECL传感平台表现出出色的灵敏度，能够快速检测Trolox，线性范围宽（0.1 μM - 1.0 mM），检测限低（LOD）为0.03 μM。该平台具有出色的重现性和长期稳定性，展示了其在实际生物传感应用中的潜力。
本研究引入了Fe-Co-PNC DAC的新概念。所证明的DAC的协同效应和增强的催化效率为先进催化剂的合理设计提供了新途径。在Trolox灵敏检测中的成功应用强调了它们在生物传感中的潜在意义。它不仅扩展了我们对SAC的理解，还为开发具有更广泛应用的高效稳定催化剂打开了大门。
