Department of Rheumatology and Clinical Immunology, First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, China.
Department of Rheumatology and Clinical Immunology, First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, China; Institute of Precision Medicine, First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, China.
Trends Endocrinol Metab. 2024 Jul;35(7):624-637. doi: 10.1016/j.tem.2024.01.005. Epub 2024 Feb 13.
Lymphocytes are crucial for protective immunity against infection and cancers; however, immune dysregulation can lead to autoimmune diseases such as systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA). Metabolic adaptation controls lymphocyte fate; thus, metabolic reprogramming can contribute to the pathogenesis of autoimmune diseases. Here, we summarize recent advances on how metabolic reprogramming determines the autoreactive and proinflammatory nature of lymphocytes in SLE and RA, unraveling molecular mechanisms and providing therapeutic targets for human autoimmune diseases.
淋巴细胞对于抗感染和癌症的保护性免疫至关重要；然而，免疫失调可导致自身免疫性疾病，如系统性红斑狼疮（SLE）和类风湿关节炎（RA）。代谢适应控制淋巴细胞命运；因此，代谢重编程可能有助于自身免疫性疾病的发病机制。在这里，我们总结了最近的进展，即代谢重编程如何决定 SLE 和 RA 中淋巴细胞的自身反应性和促炎特性，揭示了分子机制，并为人类自身免疫性疾病提供了治疗靶点。
