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一例病因不明的类固醇反应性急性肾小管损伤病例报告

A Case of Steroid-Responsive Acute Tubular Injury of Unknown Trigger: A Case Report.

作者信息

Alqaraishi Ali, Tawhari Mohammed, Alyahya Nawaf M, Alotaibi Alanoud, Ghoulah Alanoud, Aledrees Abdulrahman, Alabdulsalam Abdulrahman

机构信息

Internal Medicine, King Abdulaziz Medical City, Ministry of National Guard Health Affairs, Research Center, King Abdullah International Medical Research Centre, Riyadh, SAU.

Nephrology, King Abdulaziz Medical City, Riyadh, SAU.

出版信息

Cureus. 2024 Jan 15;16(1):e52304. doi: 10.7759/cureus.52304. eCollection 2024 Jan.

DOI:10.7759/cureus.52304
PMID:38357072
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10866087/
Abstract

Acute tubular necrosis (ATN) is a serious medical condition characterized by the rapid destruction of renal tubular epithelial cells, resulting in acute kidney injury, given its multifactorial etiologies, which can include nephrotoxic agents, ischemic insults, hypovolemia, and sepsis. We report the case of a young male patient who presented with recurrent worsening kidney function with bland sediment that was confirmed with multiple kidney biopsies as recurrent attacks of ATN of unclear etiology, which did not respond to supportive measures but did respond to steroids.

摘要

急性肾小管坏死（ATN）是一种严重的医学病症，其特征是肾小管上皮细胞迅速破坏，导致急性肾损伤。鉴于其多因素病因，包括肾毒性药物、缺血性损伤、血容量不足和败血症等。我们报告了一例年轻男性患者的病例，该患者反复出现肾功能恶化，尿沉渣正常，经多次肾活检证实为病因不明的复发性ATN发作，对支持性措施无反应，但对类固醇有反应。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8bd0/10866087/223d1d0575f2/cureus-0016-00000052304-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8bd0/10866087/ad03b5c49103/cureus-0016-00000052304-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8bd0/10866087/92209d306f62/cureus-0016-00000052304-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8bd0/10866087/223d1d0575f2/cureus-0016-00000052304-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8bd0/10866087/ad03b5c49103/cureus-0016-00000052304-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8bd0/10866087/92209d306f62/cureus-0016-00000052304-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8bd0/10866087/223d1d0575f2/cureus-0016-00000052304-i03.jpg

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A Case of Steroid-Responsive Acute Tubular Injury of Unknown Trigger: A Case Report.一例病因不明的类固醇反应性急性肾小管损伤病例报告
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本文引用的文献

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[Therapeutics for acute tubular necrosis in 2020].[2020年急性肾小管坏死的治疗方法]
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Management of Acute Kidney Injury: Core Curriculum 2018.急性肾损伤的管理：2018 年核心课程。
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KDIGO clinical practice guidelines for acute kidney injury.改善全球肾脏病预后组织（KDIGO）急性肾损伤临床实践指南
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Diagnosis and treatment of acute tubular necrosis.急性肾小管坏死的诊断与治疗
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