Feng Qingbo, Huo Chenyu, Wang Maijian, Huang Handong, Zheng Xingbin, Xie Ming
Department of General Surgery, Digestive Disease Hospital, Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou, China.
West China School of Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Front Pharmacol. 2024 Jan 31;15:1290592. doi: 10.3389/fphar.2024.1290592. eCollection 2024.
Cuproptosis is a recently discovered form of cell death that is mediated by copper (Cu) and is a non-apoptotic form of cell death related to oligomerization of lipoylated proteins and loss of Fe-S protein clusters. Since its discovery, cuproptosis has been extensively studied by researchers for its mechanism and potential applications in the treatment of cancer. Therefore, this article reviews the specific mechanism of cuproptosis currently studied, as well as its principles and strategies for use in anti-cancer treatment, with the aim of providing a reference for cuproptosis-based cancer therapy.
铜死亡是最近发现的一种细胞死亡形式，由铜（Cu）介导，是一种与脂酰化蛋白寡聚化和铁硫蛋白簇丢失相关的非凋亡性细胞死亡形式。自发现以来，铜死亡因其机制及其在癌症治疗中的潜在应用受到了研究人员的广泛研究。因此，本文综述了目前所研究的铜死亡的具体机制，以及其用于抗癌治疗的原理和策略，旨在为基于铜死亡的癌症治疗提供参考。
