加纳沃尔特地区人类免疫缺陷病毒阳性患者抗逆转录病毒治疗依从性的社会人口学和卫生系统决定因素：一项多中心研究。

Sociodemographic and health systems determinants of antiretroviral therapy adherence among human immunodeficiency virus-positive patients in the Volta Region of Ghana: A multi-centre study.

作者信息

Tarkang Elvis Enowbeyang, Manu Emmanuel, Aku Fortress Yayra, Anaman-Torgbor Judith, Khuzwayo Nelisiwe

机构信息

Department of Population and Behavioural Sciences, School of Public Health, University of Health and Allied Sciences, Hohoe, Ghana.

HIV/AIDS Prevention Research Network Cameroon, Kumba, Cameroon.

出版信息

SAGE Open Med. 2024 Feb 14;12:20503121241229056. doi: 10.1177/20503121241229056. eCollection 2024.

DOI:10.1177/20503121241229056

PMID:38357401

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10865934/

Abstract

OBJECTIVES

Optimal adherence to antiretroviral therapy is required for viral load suppression. This study investigated the sociodemographic (age, sex, marital status, level of education, monthly income, settlement type, distance to the antiretroviral therapy-providing site, ethnicity) and health system (antiretroviral therapy-providing site) determinants of antiretroviral therapy adherence among human immunodeficiency virus-positive patients in the Volta Region, Ghana.

METHODS

A cross-section design was adopted, collecting data from 1729 human immunodeficiency virus patients and analysing them using STATA version 17 at level 0.05.

RESULTS

Antiretroviral therapy adherence was poor (51.2%). Being divorced (Adjusted odds ratio (AOR) = 0.65), widow (AOR = 0.58), cohabiting (AOR = 0.22), Ewe (AOR = 3.7), Ga/Dangbe (AOR = 2.27), living in a rural area (AOR = 1.54) and an urban area (AOR = 0.64), having a monthly income of GH₵1000 or less (AOR = 3.21), covering a distance of 51 km and above to the antiretroviral therapy centre (AOR = 1.79), receiving antiretroviral therapy from Ketu South Municipal Hospital (AOR = 0.09), Hohoe Municipal Hospital (AOR = 0.03), Ho Municipal Hospital (AOR = 0.02) and Ho Teaching Hospital (AOR = 0.09) were the determinants of antiretroviral therapy adherence.

CONCLUSION

Antiretroviral therapy adherence was low. Interventions to improve antiretroviral therapy adherence should target these significant determinants.

摘要

目的

实现病毒载量抑制需要对抗逆转录病毒疗法有最佳的依从性。本研究调查了加纳沃尔特地区人类免疫缺陷病毒阳性患者中抗逆转录病毒疗法依从性的社会人口学因素（年龄、性别、婚姻状况、教育水平、月收入、居住类型、到提供抗逆转录病毒疗法地点的距离、种族）和卫生系统因素（提供抗逆转录病毒疗法的地点）。

方法

采用横断面设计，收集了1729名人类免疫缺陷病毒患者的数据，并使用STATA 17版本在0.05的水平上进行分析。

结果

抗逆转录病毒疗法的依从性较差（51.2%）。离婚（调整后的优势比（AOR）=0.65）、丧偶（AOR=0.58）、同居（AOR=0.22）、埃维族（AOR=3.7）、加族/丹贝族（AOR=2.27）、居住在农村地区（AOR=1.54）和城市地区（AOR=0.64）、月收入为1000加纳塞地或以下（AOR=3.21）、到抗逆转录病毒疗法中心的距离在51公里及以上（AOR=1.79）、在凯图南市政医院（AOR=0.09）、霍霍埃市政医院（AOR=0.03）、霍市政医院（AOR=0.02）和霍教学医院接受抗逆转录病毒疗法（AOR=0.09）是抗逆转录病毒疗法依从性的决定因素。