Hosokawa S, Nishitani H, Tomita K, Tomoyoshi T, Nishio T, Sawanishi K, Yoshida O
Uremia Invest. 1985;9(1):63-7. doi: 10.3109/08860228509104841.
We studied the behavior of copper during hemodialysis and the relationship between serum copper levels and hematologic parameters such as red blood cell count (RBC), hematocrit (Hct), hemoglobin (Hb), and serum iron in 48 hemodialyzed patients. To study diffusion, we measured copper in the arterial blood and in the dialysate at the inflow and outflow sites of the dialyzer. To study hemoconcentration, the change in hematocrit values and total serum protein values were examined. To study liberation of copper from the dialyzer membrane, copper concentrations in normal saline were measured before and after the saline was used to wash dialyzers of various kinds. We found that changes in serum copper concentration were due mainly to hemoconcentration and liberation, but partly also to diffusion, and that the net result of changes was a significant increase in serum copper. We observed no correlation between serum copper levels and RBC, Hct, Hb, and serum iron levels.
我们研究了48例血液透析患者在血液透析过程中铜的行为，以及血清铜水平与红细胞计数（RBC）、血细胞比容（Hct）、血红蛋白（Hb）和血清铁等血液学参数之间的关系。为研究扩散情况，我们在透析器的流入和流出部位测量了动脉血和透析液中的铜。为研究血液浓缩情况，检测了血细胞比容值和总血清蛋白值的变化。为研究铜从透析器膜上的释放情况，在使用生理盐水冲洗各种透析器前后测量了生理盐水中的铜浓度。我们发现血清铜浓度的变化主要归因于血液浓缩和释放，但部分也归因于扩散，并且变化的最终结果是血清铜显著增加。我们未观察到血清铜水平与RBC、Hct、Hb和血清铁水平之间存在相关性。
