RNA 聚合酶碰撞及其在转录中的作用。
RNA polymerase collisions and their role in transcription.
机构信息
Department of Chemical Biology, School of Life Sciences, Southern University of Science and Technology, Shenzhen, China.
出版信息
Transcription. 2024 Feb-Apr;15(1-2):38-47. doi: 10.1080/21541264.2024.2316972. Epub 2024 Feb 15.
Abstract
RNA polymerases are the central enzymes of gene expression and function frequently in either a head-on or co-directional manner on the busy DNA track. Whether and how these collisions between RNA polymerases contribute to transcriptional regulation is mysterious. Increasing evidence from biochemical and single-molecule studies suggests that RNA polymerase collisions function as an important regulator to fine-tune transcription, rather than creating deleterious "traffic jams". This review summarizes the recent progress on elucidating the consequences of RNA polymerase collisions during transcription and highlights the significance of cooperation and coordination between RNA polymerases.
摘要
RNA 聚合酶是基因表达的核心酶，它们在繁忙的 DNA 轨道上经常以正面或共向的方式发挥作用。这些 RNA 聚合酶之间的碰撞是否以及如何有助于转录调控是一个谜。越来越多的生化和单分子研究证据表明，RNA 聚合酶碰撞作为一种重要的调节因子，用于精细调节转录，而不是产生有害的“交通堵塞”。本文综述了近年来阐明转录过程中 RNA 聚合酶碰撞后果的最新进展，并强调了 RNA 聚合酶之间合作和协调的重要性。
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