一锅三组分合成吲哚基-4-色烯-3-磺酰氟：一类重要的药效基团。
One-Pot Three-Component Synthesis of Indolyl-4-chromene-3-sulfonyl Fluoride: A Class of Important Pharmacophore.
作者信息
Yin Cheng-Lin, Qin Richard Zijian, Qin Hua-Li
机构信息
State Key Laboratory of Silicate Materials for Architectures; and School of Chemistry, Chemical Engineering and Life Sciences, Wuhan University of Technology, Wuhan 430070, People's Republic of China.
出版信息
J Org Chem. 2024 Mar 1;89(5):3618-3628. doi: 10.1021/acs.joc.3c02706. Epub 2024 Feb 15.
A one-pot, sequential three-component reaction between salicylaldehyde, indole, and 2-bromoprop-2-ene-1-sulfonyl fluoride (BPESF) has been demonstrated for the synthesis of sulfonyl fluoride substituted 4-chromene derivatives in moderate to excellent yields (45%-94%). This one-pot sequential method features easily available starting materials, wide substrate scope, mild conditions, and great efficiency.
已证明水杨醛、吲哚与2-溴-2-丙烯-1-磺酰氟（BPESF）之间可进行一锅法连续三组分反应，以中等至优异的产率（45%-94%）合成磺酰氟取代的4-色烯衍生物。这种一锅法连续方法具有起始原料易于获得、底物范围广、条件温和且效率高的特点。
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