Tang Yifeng, Gao Wanrong
Opt Lett. 2024 Feb 15;49(4):1081-1084. doi: 10.1364/OL.515194.
A low contrast is a limiting factor for imaging a microstructure beneath the biological sample surface. In this work, we describe a novel, to our knowledge, full-field optical coherence tomography (FFOCT) system with a probe connected by a fiber bundle and a multimode optical fiber. The device is based on the tandem structure of the Michelson interferometer and the Fizeau interferometer. One advantage of our device is that light propagates through the fiber bundle only once, greatly improving detection sensitivity. In addition, by spatial filtering in the Fourier domain and inverse filtering, the effects of pixelation artifacts and multiple scattering in the en face images obtained by our system are suppressed. The depth-resolved en face images of the human finger skin ex vivo and the porcine esophagus ex vivo are presented to demonstrate the capability of our system.
低对比度是对生物样品表面下方微观结构进行成像的一个限制因素。在这项工作中，据我们所知，我们描述了一种新型的全场光学相干断层扫描（FFOCT）系统，该系统带有通过纤维束和多模光纤连接的探头。该设备基于迈克尔逊干涉仪和菲佐干涉仪的串联结构。我们设备的一个优点是光仅通过纤维束传播一次，大大提高了检测灵敏度。此外，通过傅里叶域中的空间滤波和逆滤波，我们系统获得的正面图像中的像素化伪影和多次散射的影响得到了抑制。展示了人体手指皮肤离体和猪食道离体的深度分辨正面图像，以证明我们系统的能力。
