渗出性中耳炎中的免疫复合物。

Immune complexes in otitis media with effusion.

作者信息

Yamanaka N, Somekawa Y, Himi T, Suzuki T, Kataura A

出版信息

Auris Nasus Larynx. 1985;12 Suppl 1:S70-2. doi: 10.1016/s0385-8146(85)80105-x.

Abstract

The purpose of this study was to clarify the mechanism of the chronicity of otitis media with effusion (OME). The levels of the IgG-immune complexes (IC) in middle ear effusions (MEE) were determined by using anti-C3 solid phase ELISA. The clinical significance of IC in OME was investigated, and the results were as follows: 1) IgG-IC levels in MEE were found to be significantly elevated in patients with OME and positive rates of IgG-IC in MEE were 58.3% in acute cases, 54.5% in subacute cases, and 52.5% in chronic cases. 2) There was no correlation between IgG-IC levels and IgG levels in MEE which were determined by single radial immunodiffusion method. These results suggested that immune complexes formed in the middle ear cavity might play an important role in the prolonged inflammatory process of OME.

摘要

本研究的目的是阐明分泌性中耳炎（OME）慢性化的机制。采用抗C3固相酶联免疫吸附测定法（ELISA）测定中耳积液（MEE）中IgG免疫复合物（IC）的水平。研究了IC在OME中的临床意义，结果如下：1）发现OME患者MEE中的IgG-IC水平显著升高，MEE中IgG-IC的阳性率在急性病例中为58.3%，亚急性病例中为54.5%，慢性病例中为52.5%。2）通过单向放射免疫扩散法测定的MEE中IgG-IC水平与IgG水平之间无相关性。这些结果表明，中耳腔内形成的免疫复合物可能在OME的慢性炎症过程中起重要作用。