Laurell A B, Nilsson N I, Prellner K
Acta Otolaryngol. 1980 Sep-Oct;90(3-4):290-6. doi: 10.3109/00016488009131728.
The occurrence and quantity of immune complexes in middle ear effusion (MEE) and serum, as well as serum levels of complement (C) factors were investigated in patients with chronic otitis media. Immune complexes were demonstrated in 85% of the serous MEE and in 28% of the sera. Depressed Clq values and presence of abnormal complexes, composed of subcomponents of the first C factor, indicated a disturbed function of the C system. Activation of C by the classical pathway was demonstrated in 23% of the patients. Decreased levels of properdin were also noted. The disorders within the C system tended to normalize as the otitis subsided.
对慢性中耳炎患者中耳积液（MEE）和血清中免疫复合物的出现情况及数量，以及血清补体（C）因子水平进行了研究。在85%的浆液性MEE和28%的血清中检测到免疫复合物。C1q值降低以及由第一补体因子亚成分组成的异常复合物的存在，表明补体系统功能紊乱。23%的患者通过经典途径激活补体。还观察到备解素水平降低。随着中耳炎消退，补体系统内的紊乱趋于正常化。
