与重组蛋白SARS-CoV-2疫苗相比，重复接种mRNA疫苗后IgG4抗体反应的变化。 - Suppr

Altered IgG4 antibody response to repeated mRNA versus recombinant protein SARS-CoV-2 vaccines.

作者信息

Kalkeri Raj, Zhu Mingzhu, Cloney-Clark Shane, Plested Joyce S, Parekh Anand, Gorinson Drew, Cai Rongman, Mahato Soham, Ramanathan Pradhipa, Aurelia Lidwina Carissa, Selva Kevin John, Marchese Anthony M, Fries Louis, Chung Amy W, Dunkle Lisa M

机构信息

Novavax, Inc., Gaithersburg, MD, USA.

出版信息

J Infect. 2024 Mar;88(3):106119. doi: 10.1016/j.jinf.2024.106119. Epub 2024 Feb 13.

DOI:10.1016/j.jinf.2024.106119

PMID:38360356

Abstract

摘要

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Altered IgG4 antibody response to repeated mRNA versus recombinant protein SARS-CoV-2 vaccines.与重组蛋白SARS-CoV-2疫苗相比，重复接种mRNA疫苗后IgG4抗体反应的变化。

J Infect. 2024 Mar;88(3):106119. doi: 10.1016/j.jinf.2024.106119. Epub 2024 Feb 13.

Unlikely influence of ABO blood group polymorphism on antibody response to COVID-19 mRNA vaccine against SARS-CoV-2 spike protein.ABO血型多态性对针对严重急性呼吸综合征冠状病毒2（SARS-CoV-2）刺突蛋白的新冠病毒mRNA疫苗抗体反应的影响不大。

Vox Sang. 2022 Sep;117(9):1126-1127. doi: 10.1111/vox.13341. Epub 2022 Aug 2.

Response to 'Unlikely influence of ABO blood group polymorphism on antibody response to COVID-19 mRNA vaccine against SARS-CoV-2 spike protein'.对《ABO血型多态性对COVID-19 mRNA疫苗针对SARS-CoV-2刺突蛋白抗体反应的影响不太可能》的回应

Vox Sang. 2022 Sep;117(9):1128. doi: 10.1111/vox.13340. Epub 2022 Aug 2.

Differential Antibody Response to mRNA COVID-19 Vaccines in Healthy Subjects.健康受试者对 mRNA COVID-19 疫苗的抗体反应差异。

Microbiol Spectr. 2021 Sep 3;9(1):e0034121. doi: 10.1128/Spectrum.00341-21. Epub 2021 Aug 4.

Antibody response after two doses of homologous or heterologous SARS-CoV-2 vaccines in healthcare workers at health promotion centers: A prospective observational study.在促进健康中心工作的医护人员中，同源或异源 SARS-CoV-2 疫苗接种两剂后的抗体反应：一项前瞻性观察研究。

J Med Virol. 2022 Oct;94(10):4719-4726. doi: 10.1002/jmv.27911. Epub 2022 Jun 14.

Antibody-dependent neutralizing capacity of the SARS-CoV-2 vaccine BNT162b2 with and without previous COVID-19 priming.有或无前新冠病毒感染启动的情况下，SARS-CoV-2疫苗BNT162b2的抗体依赖性中和能力

J Intern Med. 2021 Dec;290(6):1272-1274. doi: 10.1111/joim.13366. Epub 2021 Aug 2.

Antibody response to SARS-CoV-2 booster vaccines.对新冠病毒加强疫苗的抗体反应。

Clin Biochem. 2022 Sep;107:80-82. doi: 10.1016/j.clinbiochem.2022.06.004. Epub 2022 Jun 15.

Antibody response to three SARS-CoV-2 mRNA vaccines in adolescent solid organ transplant recipients.青少年实体器官移植受者对三种SARS-CoV-2 mRNA疫苗的抗体反应。

Am J Transplant. 2022 Oct;22(10):2481-2483. doi: 10.1111/ajt.17085. Epub 2022 May 13.

Impact of Vaccine-Elicited Anti-Spike IgG4 Antibodies on Fc-Effector Functions Against SARS-CoV-2.疫苗诱导的抗刺突IgG4抗体对针对严重急性呼吸综合征冠状病毒2（SARS-CoV-2）的Fc效应器功能的影响

Viruses. 2025 May 3;17(5):666. doi: 10.3390/v17050666.

Serum antibody response in patients with philadelphia-chromosome positive or negative myeloproliferative neoplasms following vaccination with SARS-CoV-2 spike protein messenger RNA (mRNA) vaccines.接种严重急性呼吸综合征冠状病毒2（SARS-CoV-2）刺突蛋白信使核糖核酸（mRNA）疫苗后，费城染色体阳性或阴性骨髓增殖性肿瘤患者的血清抗体反应。

Leukemia. 2021 Dec;35(12):3578-3580. doi: 10.1038/s41375-021-01457-1. Epub 2021 Nov 5.

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Hum Vaccin Immunother. 2025 Dec;21(1):2547517. doi: 10.1080/21645515.2025.2547517. Epub 2025 Aug 14.

Circulating Antibodies Against Common Cold Coronaviruses Do Not Interfere with Immune Responses to Primary or Booster SARS-CoV-2 mRNA Vaccines.针对普通感冒冠状病毒的循环抗体不会干扰对SARS-CoV-2 mRNA 疫苗初次或加强免疫的免疫反应。

Vaccines (Basel). 2025 May 21;13(5):547. doi: 10.3390/vaccines13050547.

Estimating population immunity to SARS-CoV-2 by random sampling from primary and secondary healthcare in Scotland, May 2024.2024年5月通过对苏格兰初级和二级医疗保健机构进行随机抽样来评估人群对新冠病毒的免疫力。

EBioMedicine. 2025 Jun;116:105760. doi: 10.1016/j.ebiom.2025.105760. Epub 2025 May 16.

T and B cell responses in different immunization scenarios for COVID-19: a narrative review.COVID-19不同免疫方案中的T细胞和B细胞反应：一项叙述性综述

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Evaluation of antibody responses in healthy individuals receiving SARS-CoV-2 inactivated vaccines.对接种新型冠状病毒灭活疫苗的健康个体的抗体反应评估。

Biosaf Health. 2024 Apr 19;6(3):153-164. doi: 10.1016/j.bsheal.2024.04.001. eCollection 2024 Jun.

Increased SARS-CoV-2 IgG4 has variable consequences dependent upon Fc function, Fc receptor polymorphism, and viral variant.严重急性呼吸综合征冠状病毒2（SARS-CoV-2）IgG4增加会因Fc功能、Fc受体多态性和病毒变体而产生不同后果。

Sci Adv. 2025 Feb 28;11(9):eads1482. doi: 10.1126/sciadv.ads1482. Epub 2025 Feb 26.

Immunosuppressive Therapy Modifies Anti-Spike IgG Subclasses Distribution After Four Doses of mRNA Vaccination in a Cohort of Kidney Transplant Recipients.免疫抑制疗法改变了一组肾移植受者在四剂 mRNA 疫苗接种后的抗刺突 IgG 亚类分布。

Vaccines (Basel). 2025 Jan 25;13(2):123. doi: 10.3390/vaccines13020123.

Rethinking Optimal Immunogens to Face SARS-CoV-2 Evolution Through Vaccination.通过疫苗接种重新思考应对新冠病毒进化的最佳免疫原

Influenza Other Respir Viruses. 2025 Jan;19(1):e70076. doi: 10.1111/irv.70076.

Repeated COVID-19 mRNA vaccination results in IgG4 class switching and decreased NK cell activation by S1-specific antibodies in older adults.重复接种新冠病毒mRNA疫苗可导致老年人体内IgG4类别转换，并降低S1特异性抗体对自然杀伤细胞的激活作用。

Immun Ageing. 2024 Sep 14;21(1):63. doi: 10.1186/s12979-024-00466-9.

An unexpected IgE anti-receptor binding domain response following natural infection and different types of SARS-CoV-2 vaccines.自然感染和不同类型的 SARS-CoV-2 疫苗接种后出现的意外 IgE 抗受体结合域反应。

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Altered IgG4 antibody response to repeated mRNA versus recombinant protein SARS-CoV-2 vaccines.

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