与重组蛋白SARS-CoV-2疫苗相比，重复接种mRNA疫苗后IgG4抗体反应的变化。 - Suppr

Altered IgG4 antibody response to repeated mRNA versus recombinant protein SARS-CoV-2 vaccines.

作者信息

Kalkeri Raj, Zhu Mingzhu, Cloney-Clark Shane, Plested Joyce S, Parekh Anand, Gorinson Drew, Cai Rongman, Mahato Soham, Ramanathan Pradhipa, Aurelia Lidwina Carissa, Selva Kevin John, Marchese Anthony M, Fries Louis, Chung Amy W, Dunkle Lisa M

机构信息

Novavax, Inc., Gaithersburg, MD, USA.

出版信息

J Infect. 2024 Mar;88(3):106119. doi: 10.1016/j.jinf.2024.106119. Epub 2024 Feb 13.

DOI:10.1016/j.jinf.2024.106119

PMID:38360356

Abstract

摘要

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Altered IgG4 antibody response to repeated mRNA versus recombinant protein SARS-CoV-2 vaccines.与重组蛋白SARS-CoV-2疫苗相比，重复接种mRNA疫苗后IgG4抗体反应的变化。

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Impact of Vaccine-Elicited Anti-Spike IgG4 Antibodies on Fc-Effector Functions Against SARS-CoV-2.疫苗诱导的抗刺突IgG4抗体对针对严重急性呼吸综合征冠状病毒2（SARS-CoV-2）的Fc效应器功能的影响

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Serum antibody response in patients with philadelphia-chromosome positive or negative myeloproliferative neoplasms following vaccination with SARS-CoV-2 spike protein messenger RNA (mRNA) vaccines.接种严重急性呼吸综合征冠状病毒2（SARS-CoV-2）刺突蛋白信使核糖核酸（mRNA）疫苗后，费城染色体阳性或阴性骨髓增殖性肿瘤患者的血清抗体反应。

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Increased SARS-CoV-2 IgG4 has variable consequences dependent upon Fc function, Fc receptor polymorphism, and viral variant.严重急性呼吸综合征冠状病毒2（SARS-CoV-2）IgG4增加会因Fc功能、Fc受体多态性和病毒变体而产生不同后果。

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Altered IgG4 antibody response to repeated mRNA versus recombinant protein SARS-CoV-2 vaccines.

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