Byun Jin Young, Lee Min Kyoung, Jung So Lyung
J Korean Soc Radiol. 2024 Jan;85(1):184-196. doi: 10.3348/jksr.2023.0065. Epub 2023 Dec 9.
We investigated potentially promising imaging findings and their combinations in the evaluation of cognitive decline.
This retrospective study included 138 patients with subjective cognitive impairments, who underwent brain MRI. We classified the same group of patients into Alzheimer's disease (AD) and non-AD groups, based on the neuropsychiatric evaluation. We analyzed imaging findings, including white matter hyperintensity (WMH) and cerebral microbleeds (CMBs), using the Kruskal-Wallis test for group comparison, and receiver operating characteristic (ROC) curve analysis for assessing the diagnostic performance of imaging findings.
CMBs in the lobar or deep locations demonstrated higher prevalence in the patients with AD compared to those in the non-AD group. The presence of lobar CMBs combined with periventricular WMH (area under the ROC curve [AUC] = 0.702 [95% confidence interval: 0.599-0.806], < 0.001) showed the highest performance in differentiation of AD from non-AD group.
Combinations of imaging findings can serve as useful additive diagnostic tools in the assessment of cognitive decline.
我们研究了在评估认知衰退方面潜在有前景的影像学表现及其组合。
这项回顾性研究纳入了138例主观认知障碍患者，他们均接受了脑部MRI检查。基于神经精神评估，我们将同一组患者分为阿尔茨海默病（AD）组和非AD组。我们分析了影像学表现，包括白质高信号（WMH）和脑微出血（CMB），使用Kruskal-Wallis检验进行组间比较，并使用受试者操作特征（ROC）曲线分析来评估影像学表现的诊断性能。
与非AD组相比，AD患者脑叶或深部的CMB患病率更高。脑叶CMB与脑室周围WMH同时存在（ROC曲线下面积[AUC]=0.702[95%置信区间：0.599 - 0.806]，<0.001）在区分AD组和非AD组方面表现最佳。
影像学表现的组合可作为评估认知衰退的有用辅助诊断工具。
