Center for Mass Spectrometry and Optical Spectroscopy, Mannheim University of Applied Sciences, 68163, Mannheim, Germany.
Interdisciplinary Center for Neurosciences, Heidelberg University, 69117, Heidelberg, Germany.
J Muscle Res Cell Motil. 2024 Jun;45(2):79-86. doi: 10.1007/s10974-024-09665-9. Epub 2024 Feb 17.
Neuromuscular junctions are the synapses between motor neurons and skeletal muscle fibers, which mediate voluntary muscle movement. Since neuromuscular junctions are also tightly associated with the capping function of terminal Schwann cells, these synapses have been classically regarded as tripartite chemical synapses. Although evidences from sympathetic innervation of neuromuscular junctions was described approximately a century ago, the essential presence and functional relevance of sympathetic contribution to the maintenance and modulation of neuromuscular junctions was demonstrated only recently. These findings shed light on the pathophysiology of different clinical conditions and can optimize surgical and clinical treatment modalities for skeletal muscle disorders.
神经肌肉接头是运动神经元和骨骼肌纤维之间的突触，介导随意肌运动。由于神经肌肉接头也与终末施万细胞的盖帽功能密切相关，这些突触通常被视为三突触化学突触。尽管大约一个世纪前就描述了神经肌肉接头的交感神经支配的证据，但直到最近才证明交感神经对神经肌肉接头的维持和调节的重要存在和功能相关性。这些发现为不同临床情况的病理生理学提供了线索，并可以优化骨骼肌疾病的手术和临床治疗方式。
