Xue Wenjing, Shi Xiaoyu, Guo Jiaming, Wen Siqi, Lin Weilong, He Qi, Gao Yang, Wang Rongzhong, Xu Yiqun
College of Environmental Science and Engineering, Yangzhou University, Yangzhou 225009, PR China.
School of Hydraulic and Environmental Engineering, Changsha University of Science & Technology, Changsha 410114, PR China.
Water Res. 2024 Apr 1;253:121309. doi: 10.1016/j.watres.2024.121309. Epub 2024 Feb 12.
Antibiotics and antibiotic resistance genetic pollution have become a global environmental and health concern recently, with frequent detection in various environmental media. Therefore, finding ways to control antibiotics and antibiotic resistance genes (ARGs) is urgently needed. Nano zero-valent iron (nZVI) has shown a positive effect on antibiotics degradation and restraining ARGs, making it a promising solution for controlling antibiotics and ARGs. However, given the current increasingly fragmented research focus and results, a comprehensive review is still lacking. In this work, we first introduce the origin and transmission of antibiotics and ARGs in various environmental media, and then discuss the affecting factors during the degradation of antibiotics and the control of ARGs by nZVI and modified nZVI, including pH, nZVI dose, and oxidant concentration, etc. Then, the mechanisms of antibiotic and ARGs removal promoted by nZVI are also summarized. In general, the mechanism of antibiotic degradation by nZVI mainly includes adsorption and reduction, while promoting the biodegradation of antibiotics by affecting the microbial community. nZVI can also be combined with persulfates to degrade antibiotics through advanced oxidation processes. For the control of ARGs, nZVI not only changes the microbial community structure, but also affects the proliferation of ARGs through affecting the fate of mobile genetic elements (MGEs). Finally, some new ideas on the application of nZVI in the treatment of antibiotic resistance are proposed. This paper provides a reference for research and application in this field.
抗生素及抗生素抗性基因污染近来已成为全球环境与健康领域的一大关注点，在各种环境介质中频繁被检测到。因此，迫切需要找到控制抗生素及抗生素抗性基因（ARGs）的方法。纳米零价铁（nZVI）已在抗生素降解及抑制ARGs方面展现出积极效果，使其成为控制抗生素及ARGs的一种有前景的解决方案。然而，鉴于当前研究重点和结果日益分散，仍缺乏全面的综述。在这项工作中，我们首先介绍抗生素及ARGs在各种环境介质中的来源与传播，接着讨论nZVI及改性nZVI在抗生素降解和ARGs控制过程中的影响因素，包括pH值、nZVI剂量和氧化剂浓度等。然后，还总结了nZVI促进抗生素及ARGs去除的机制。总体而言，nZVI降解抗生素的机制主要包括吸附和还原，同时通过影响微生物群落促进抗生素的生物降解。nZVI还可与过硫酸盐结合，通过高级氧化过程降解抗生素。对于ARGs的控制，nZVI不仅改变微生物群落结构，还通过影响移动遗传元件（MGEs）的命运来影响ARGs的增殖。最后，提出了关于nZVI在抗生素抗性治理中应用的一些新思路。本文为该领域的研究与应用提供了参考。
