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习惯性打鼾与高血压失控有关。

Regular snoring is associated with uncontrolled hypertension.

作者信息

Lechat Bastien, Naik Ganesh, Appleton Sarah, Manners Jack, Scott Hannah, Nguyen Duc Phuc, Escourrou Pierre, Adams Robert, Catcheside Peter, Eckert Danny J

机构信息

Adelaide Institute for Sleep Health and FHMRI Sleep Health, College of Medicine and Public Health, Flinders University, Adelaide, Australia.

Centre Interdisciplinaire du Sommeil, Paris, France.

出版信息

NPJ Digit Med. 2024 Feb 17;7(1):38. doi: 10.1038/s41746-024-01026-7.

Abstract

Snoring may be a risk factor for cardiovascular disease independent of other co-morbidities. However, most prior studies have relied on subjective, self-report, snoring evaluation. This study assessed snoring prevalence objectively over multiple months using in-home monitoring technology, and its association with hypertension prevalence. In this study, 12,287 participants were monitored nightly for approximately six months using under-the-mattress sensor technology to estimate the average percentage of sleep time spent snoring per night and the estimated apnea-hypopnea index (eAHI). Blood pressure cuff measurements from multiple daytime assessments were averaged to define uncontrolled hypertension based on mean systolic blood pressure≥140 mmHg and/or a mean diastolic blood pressure ≥90 mmHg. Associations between snoring and uncontrolled hypertension were examined using logistic regressions controlled for age, body mass index, sex, and eAHI. Participants were middle-aged (mean ± SD; 50 ± 12 y) and most were male (88%). There were 2467 cases (20%) with uncontrolled hypertension. Approximately 29, 14 and 7% of the study population snored for an average of >10, 20, and 30% per night, respectively. A higher proportion of time spent snoring (75th vs. 5th; 12% vs. 0.04%) was associated with a ~1.9-fold increase (OR [95%CI]; 1.87 [1.63, 2.15]) in uncontrolled hypertension independent of sleep apnea. Multi-night objective snoring assessments and repeat daytime blood pressure recordings in a large global consumer sample, indicate that snoring is common and positively associated with hypertension. These findings highlight the potential clinical utility of simple, objective, and noninvasive methods to detect snoring and its potential adverse health consequences.

摘要

打鼾可能是心血管疾病的一个风险因素,独立于其他合并症。然而,大多数先前的研究依赖于主观的自我报告打鼾评估。本研究使用家庭监测技术客观评估了多个月的打鼾患病率及其与高血压患病率的关联。在本研究中,12287名参与者使用床垫下传感器技术每晚监测约六个月,以估计每晚打鼾睡眠时间的平均百分比和估计的呼吸暂停低通气指数(eAHI)。多次白天评估的血压袖带测量值进行平均,以根据平均收缩压≥140mmHg和/或平均舒张压≥90mmHg定义未控制的高血压。使用对年龄、体重指数、性别和eAHI进行控制的逻辑回归来检验打鼾与未控制高血压之间的关联。参与者为中年(平均±标准差;50±12岁),大多数为男性(88%)。有2467例(20%)患有未控制的高血压。分别约有29%、14%和7%的研究人群每晚平均打鼾时间>10%、20%和30%。在独立于睡眠呼吸暂停的情况下,打鼾时间比例较高(第75百分位数与第5百分位数;12%与0.04%)与未控制高血压增加约1.9倍(OR[95%CI];1.87[1.63,2.15])相关。在一个大型全球消费者样本中进行的多晚客观打鼾评估和重复的白天血压记录表明,打鼾很常见,并且与高血压呈正相关。这些发现凸显了简单、客观和无创方法检测打鼾及其潜在不良健康后果的潜在临床实用性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a244/10874387/2b37df95a4cd/41746_2024_1026_Fig1_HTML.jpg

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