Barthélemy C, Woehrlé R, Simon J
Drugs Exp Clin Res. 1985;11(10):675-8.
40 749 RP, an N-methyl-2-(2-pyridyl)-2,3,4,5-tetrahydro-2-thiophene carbothioamide derivative, is already known as a potent gastric antisecretory agent in animals and in man. In order to determine its duration of action, its activity was investigated on Histalog-stimulated gastric acid secretion in 6 healthy volunteers. The efficacy of a 2 mg/kg dose, compared with that of placebo, was potent, and remained the same when the drug was ingested 6 h before stimulation instead of 1 h. The duration of action of 40 749 RP is therefore longer than 6 h.
40 749 RP是一种N-甲基-2-(2-吡啶基)-2,3,4,5-四氢-2-噻吩碳硫酰胺衍生物，在动物和人体中已被公认为一种强效的胃抗分泌剂。为了确定其作用持续时间，在6名健康志愿者身上研究了它对组胺刺激的胃酸分泌的活性。与安慰剂相比，2 mg/kg剂量的疗效显著，且在刺激前6小时而非1小时服用该药物时，疗效保持不变。因此，40 749 RP的作用持续时间超过6小时。
