Berndt V
Fortschr Med. 1978 Mar 9;96(9):467-70.
In 5 series of dogs the acute effect of a high dose of prednisolone (40 mg/kg i.v.) on Histalog stimulated gastric secretion (5 mg/kg s.c.) was tested. There was no effect of prednisolone alone. The combination of Histalog and prednisolone showed a potentiation of Histalog stimulation in high range. The effect was not seen when truncal vagotomy was performed before stimulation. It is possible that there is a cholinergic reaction or an interaction in the metabolism of histamine.
在5组犬中，测试了高剂量泼尼松龙（静脉注射40毫克/千克）对组胺刺激的胃酸分泌（皮下注射5毫克/千克）的急性作用。单独使用泼尼松龙没有效果。组胺和泼尼松龙的组合在高剂量范围内显示出对组胺刺激的增强作用。在刺激前进行迷走神经切断术时未观察到这种作用。组胺可能存在胆碱能反应或在代谢过程中有相互作用。
