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功能近红外光谱技术(fNIRS)在耳鸣研究中的应用:当代见解与展望。

Application of functional near-infrared spectroscopy (fNIRS) in tinnitus research: contemporary insights and perspectives.

作者信息

Hu Hantong, Lin Xiaoqi, Ye Ziyu, Fang Lianqiang, Gao Hong, Zhang Quanai

机构信息

Department of Acupuncture and Moxibustion, The Third Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, China.

Department of Neurobiology and Acupuncture Research, Key Laboratory of Acupuncture and Neurology of Zhejiang Province, Zhejiang Chinese Medical University, Hangzhou, China.

出版信息

Front Psychol. 2024 Feb 2;15:1334660. doi: 10.3389/fpsyg.2024.1334660. eCollection 2024.

Abstract

Tinnitus, characterized by phantom sound perception, is a highly disruptive condition lacking clearly effective treatments. Its complex neural mechanisms are not fully elucidated. Functional near-infrared spectroscopy (fNIRS) is a promising neuroimaging tool well-suited for assessing tinnitus due to its quietness, portability, and ability to directly measure cortical hemodynamic responses. This study timely summarizes the recent applications of fNIRS in investigating tinnitus pathology, correlating neuroimaging biomarkers with symptom severity, and evaluating treatment efficacy. Further studies with larger samples are warranted to reproduce existing findings. Thus, fNIRS appears to be a promising tool in tinnitus research. Addressing technical limitations, optimizing control groups, advancing data analysis, integrating standardized, and individualized experimental protocols can facilitate the extended and robust utilization of fNIRS in tinnitus research.

摘要

耳鸣以幻听为特征,是一种极具干扰性的病症,目前缺乏明确有效的治疗方法。其复杂的神经机制尚未完全阐明。功能近红外光谱技术(fNIRS)是一种很有前景的神经成像工具,因其安静、便携以及能够直接测量皮层血流动力学反应,非常适合用于评估耳鸣。本研究及时总结了fNIRS在耳鸣病理学研究、神经成像生物标志物与症状严重程度的相关性研究以及治疗效果评估方面的最新应用。有必要开展更大样本量的进一步研究以重现现有研究结果。因此,fNIRS似乎是耳鸣研究中一种很有前景的工具。解决技术局限性、优化对照组、推进数据分析、整合标准化和个性化实验方案,能够促进fNIRS在耳鸣研究中的广泛且可靠应用。

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