Department of Bioengineering, Temple University, Philadelphia, Pennsylvania, United States.
Am J Physiol Cell Physiol. 2024 Apr 1;326(4):C1212-C1225. doi: 10.1152/ajpcell.00633.2023. Epub 2024 Feb 19.
Fibronectin (FN) is a major extracellular matrix (ECM) protein involved in a wide range of physiological processes, including cell migration. These FN-mediated cell migration events are essential to processes such as wound repair, cancer metastasis, and vertebrate development. This review synthesizes mainly current literature to provide an overview of the mechanoregulatory role of FN-mediated cell migration. Background on FN structure and role in mechanotransduction is provided. Cell migration concepts are introduced, including the general cell migration mechanism and classification of cell migration types. Then, FN-mediated events that directly affect cell migration are explored. Finally, a focus on FN in tissue repair and cancer migration is presented, as these topics represent a large amount of current research.
纤连蛋白（FN）是一种主要的细胞外基质（ECM）蛋白，参与多种生理过程，包括细胞迁移。这些 FN 介导的细胞迁移事件对于伤口修复、癌症转移和脊椎动物发育等过程至关重要。本综述主要综合了当前的文献，提供了 FN 介导的细胞迁移的机械调节作用概述。提供了 FN 结构和在机械转导中作用的背景。引入了细胞迁移的概念，包括一般的细胞迁移机制和细胞迁移类型的分类。然后，探讨了直接影响细胞迁移的 FN 介导事件。最后，重点介绍了 FN 在组织修复和癌症迁移中的作用，因为这些主题代表了大量当前的研究。
