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谁应该接受晚期胃食管癌症的免疫治疗?

Who Should Receive Immunotherapy for Advanced Gastroesophageal Cancer?

机构信息

Department of Medicine, Division of Hematology & Oncology, University of Pittsburgh Medical Center (UPMC), Pittsburgh, PA, USA.

Novant Health Cancer Institute, Charlotte, NC, USA.

出版信息

Curr Treat Options Oncol. 2024 Apr;25(4):496-509. doi: 10.1007/s11864-024-01189-1. Epub 2024 Feb 19.

DOI:10.1007/s11864-024-01189-1
PMID:38372852
Abstract

This paper shines a light on the exciting progress being made in using immunotherapy to treat advanced gastroesophageal cancers. The positive results from trials using drugs like Pembrolizumab and Nivolumab are certainly encouraging and open new possibilities for treating this challenging disease. However, it is clear that we still have a lot to learn about how to predict which patients will benefit most from these treatments. The exploration of combining therapies and using machine learning to guide treatment shows promise. Moving forward, it is crucial that researchers and healthcare professionals continue to work together, sharing knowledge and findings to continue the advancements in this important area.

摘要

本文探讨了免疫疗法在治疗晚期胃食管癌症方面取得的令人振奋的进展。使用 Pembrolizumab 和 Nivolumab 等药物的试验结果确实令人鼓舞,为治疗这种具有挑战性的疾病开辟了新的可能性。然而,很明显,我们仍然需要了解更多关于如何预测哪些患者将从这些治疗中获益最大的知识。探索联合治疗和使用机器学习来指导治疗显示出了希望。展望未来,研究人员和医疗保健专业人员继续合作,分享知识和发现,以继续推动这一重要领域的进展至关重要。

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1
Who Should Receive Immunotherapy for Advanced Gastroesophageal Cancer?谁应该接受晚期胃食管癌症的免疫治疗?
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2
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本文引用的文献

1
Trastuzumab deruxtecan in patients in the USA and Europe with HER2-positive advanced gastric or gastroesophageal junction cancer with disease progression on or after a trastuzumab-containing regimen (DESTINY-Gastric02): primary and updated analyses from a single-arm, phase 2 study.曲妥珠单抗 deruxtecan 用于美国和欧洲的曲妥珠单抗治疗后疾病进展的 HER2 阳性晚期胃或胃食管交界处癌患者(DESTINY-Gastric02):一项单臂、2 期研究的主要和更新分析。
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Cabozantinib plus durvalumab in advanced gastroesophageal cancer and other gastrointestinal malignancies: Phase Ib CAMILLA trial results.卡博替尼联合度伐利尤单抗治疗晚期胃食管腺癌和其他胃肠道恶性肿瘤:Ib 期 CAMILLA 试验结果。
Cell Rep Med. 2023 Feb 21;4(2):100916. doi: 10.1016/j.xcrm.2023.100916. Epub 2023 Jan 25.
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Effectiveness of Immune Checkpoint Inhibitors in Patients With Advanced Esophageal Squamous Cell Carcinoma: A Meta-analysis Including Low PD-L1 Subgroups.免疫检查点抑制剂治疗晚期食管鳞癌患者的疗效:包括低 PD-L1 亚组的荟萃分析。
JAMA Oncol. 2023 Feb 1;9(2):215-224. doi: 10.1001/jamaoncol.2022.5816.
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Immune Checkpoint Inhibitors in Cancer Therapy.癌症治疗中的免疫检查点抑制剂。
Curr Oncol. 2022 Apr 24;29(5):3044-3060. doi: 10.3390/curroncol29050247.
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Nivolumab plus chemotherapy or ipilimumab in gastro-oesophageal cancer.纳武利尤单抗联合化疗或伊匹单抗用于胃食管交界处癌。
Nature. 2022 Mar;603(7903):942-948. doi: 10.1038/s41586-022-04508-4. Epub 2022 Mar 23.
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Nivolumab Combination Therapy in Advanced Esophageal Squamous-Cell Carcinoma.纳武利尤单抗联合治疗晚期食管鳞癌。
N Engl J Med. 2022 Feb 3;386(5):449-462. doi: 10.1056/NEJMoa2111380.
7
Nivolumab plus chemotherapy versus placebo plus chemotherapy in patients with HER2-negative, untreated, unresectable advanced or recurrent gastric or gastro-oesophageal junction cancer (ATTRACTION-4): a randomised, multicentre, double-blind, placebo-controlled, phase 3 trial.纳武利尤单抗联合化疗对比安慰剂联合化疗用于治疗人表皮生长因子受体 2(HER2)阴性、未经治疗、不可切除的晚期或复发性胃或胃食管结合部腺癌患者(ATTRACTION-4):一项随机、多中心、双盲、安慰剂对照、3 期临床试验。
Lancet Oncol. 2022 Feb;23(2):234-247. doi: 10.1016/S1470-2045(21)00692-6. Epub 2022 Jan 11.
8
The KEYNOTE-811 trial of dual PD-1 and HER2 blockade in HER2-positive gastric cancer.KEYNOTE-811 试验:双 PD-1 和 HER2 阻断在 HER2 阳性胃癌中的应用。
Nature. 2021 Dec;600(7890):727-730. doi: 10.1038/s41586-021-04161-3. Epub 2021 Dec 15.
9
Immune-Checkpoint Inhibition in the Treatment of Gastro-Esophageal Cancer: A Closer Look at the Emerging Evidence.免疫检查点抑制剂在胃食管癌治疗中的应用:深入探究新出现的证据
Cancers (Basel). 2021 Nov 25;13(23):5929. doi: 10.3390/cancers13235929.
10
Immunotherapy Predictive Molecular Markers in Advanced Gastroesophageal Cancer: MSI and Beyond.晚期胃食管癌的免疫治疗预测分子标志物:微卫星高度不稳定及其他相关标志物
Cancers (Basel). 2021 Apr 5;13(7):1715. doi: 10.3390/cancers13071715.