Bruni J F, Watkins W B, Yen S S
J Clin Endocrinol Metab. 1979 Oct;49(4):649-51. doi: 10.1210/jcem-49-4-649.
Using a specific antiserum, beta-endorphin was quantitated in 8 human pancreas obtained at autopsy by radioimmunoassay and localized by immunocytochemistry. The mean (+/- SE) concentration of beta-endorphin in pancreatic extracts of 5 non-diabetic adults was 13.5 +/- 9.8 ng/gm with a range of 2.1 to 52.8 ng/gm of tissue. Pancreatic beta-endorphin concentration in two premature infants were within the range found in adults. In one diabetic pancreas, there was no measurable beta-endorphin. Specific beta-endorphin immunofluorescence is localized within the pancreatic islets. This finding suggests that beta-endorphin may participate in intraislet regulation of pancreatic hormone secretion.
使用一种特异性抗血清，通过放射免疫分析法对8例尸检获得的人类胰腺中的β-内啡肽进行定量，并通过免疫细胞化学进行定位。5名非糖尿病成年人胰腺提取物中β-内啡肽的平均（±标准误）浓度为13.5±9.8 ng/g，组织范围为2.1至52.8 ng/g。两名早产儿的胰腺β-内啡肽浓度在成人发现的范围内。在一个糖尿病胰腺中，未检测到可测量的β-内啡肽。特异性β-内啡肽免疫荧光定位于胰岛内。这一发现表明β-内啡肽可能参与胰岛内胰腺激素分泌的调节。
