Lee Jonghoo, Park Hye Kyeong, Kwon Min-Jung, Ham Soo-Youn, Gil Hyun-Il, Lim Si-Young, Song Jae-Uk
Department of Internal Medicine, Jeju National University Hospital, Jeju National University School of Medicine, Jeju, Korea.
Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Ilsan Paik Hospital, Inje University College of Medicine, Goyang, Korea.
J Korean Med Sci. 2024 Feb 19;39(6):e51. doi: 10.3346/jkms.2024.39.e51.
Lung dysfunction and high apolipoprotein B/apolipoprotein A-I (apoB/apoA-I) ratio are both recognized risk factors for cardiovascular disease. However, few studies have examined the association between the apoB/ApoA-I ratio and lung function. Therefore, we investigated whether this ratio is associated with decreased lung function in a large healthy cohort.
We performed a cohort study on 68,418 healthy Koreans (34,797 males, mean age: 38.1 years) who underwent a health examination in 2019. ApoB/apoA-I ratio was categorized into quartiles. Spirometric values at the fifth percentile in our population were considered the lower limit of normal (LLN), which was used to define lung function impairment. Adjusted odds ratios (aORs) and 95% confidence intervals (CIs), using the lowest quartile as the reference, were estimated to determine lung function impairment.
Mean apoB/apoA-I ratio was 0.67 ± 0.21. Subjects with the highest quartile of this ratio had the lowest predicted forced expiratory volume in one second (FEV%) and forced vital capacity (FVC%) after controlling for covariates ( < 0.001). However, FEV/FVC ratio was not significantly different among the four quartiles ( = 0.059). Compared with the lowest quartile (Q1, reference), the aORs (95% CI) for FEV% < LLN across increasing quartiles (from Q2 to Q4) were 1.216 (1.094-1.351), 1.293 (1.156-1.448), and 1.481 (1.311-1.672) ( for trend < 0.001), respectively. Similarly, the aORs for FVC% < LLN compared with the reference were 1.212 (1.090-1.348), 1.283 (1.147-1.436), and 1.502 (1.331-1.695) with increasing quartiles ( for trend < 0.001). However, the aORs for FEV/FVC < LLN were not significantly different among groups ( for trend = 0.273).
High apoB/apoA-I ratio was associated with decreased lung function. However, longitudinal follow-up studies are required to validate our findings.
肺功能障碍和高载脂蛋白B/载脂蛋白A-I（apoB/apoA-I）比值均为公认的心血管疾病风险因素。然而，很少有研究探讨apoB/ApoA-I比值与肺功能之间的关联。因此，我们在一个大型健康队列中调查了该比值是否与肺功能下降有关。
我们对2019年接受健康检查的68418名健康韩国人（34797名男性，平均年龄：38.1岁）进行了队列研究。apoB/apoA-I比值被分为四分位数。我们将人群中第五百分位数的肺量计值视为正常下限（LLN），用于定义肺功能损害。以最低四分位数为参照，估计调整后的比值比（aORs）和95%置信区间（CIs），以确定肺功能损害情况。
apoB/apoA-I比值的平均值为0.67±0.21。在控制协变量后，该比值处于最高四分位数的受试者一秒用力呼气量（FEV%）和用力肺活量（FVC%）的预测值最低（<0.001）。然而，FEV/FVC比值在四个四分位数之间无显著差异（=0.059）。与最低四分位数（Q1，参照）相比，随着四分位数增加（从Q2到Q4），FEV%<LLN的aORs（95%CI）分别为1.216（1.094 - 1.351）、1.293（1.156 - 1.448）和1.481（1.311 - 1.672）（趋势检验<0.001）。同样，与参照相比，随着四分位数增加，FVC%<LLN的aORs分别为1.212（1.090 - 1.348）、1.283（1.147 - 1.436）和1.502（1.331 - 1.695）（趋势检验<0.001）。然而，FEV/FVC<LLN的aORs在各组之间无显著差异（趋势检验=0.273）。
高apoB/apoA-I比值与肺功能下降有关。然而，需要进行纵向随访研究来验证我们的发现。
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