Division of Pulmonary, Allergy and Critical Care Medicine, Department of Internal Medicine, Yeouido St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
Sci Rep. 2024 Nov 27;14(1):29502. doi: 10.1038/s41598-024-80055-4.
Previous studies suggest associations between the risk of developing chronic obstructive pulmonary disease (COPD) and adiponectin/leptin (ALR) and apolipoprotein B/A1 (APOR) ratios. This longitudinal observational study, using data from the Korean Genome and Epidemiology Study (KoGES), examined the rate of lung function decline, risk factors for the airflow obstruction (AFO), and the time to first AFO based on ALR and APOR groups. Among 5578 participants, high ALR and low APOR were associated with rapid decline in lung function and a shorter time to the first AFO. The high ALR group and the combined high ALR and low APOR group showed higher risk of experiencing AFO both at least once (RR 1.46, 95% CI 1.12-1.90; RR 1.74, 95% CI 1.23-2.46, respectively) and at the final follow up (RR 1.44, 95% CI 1.05-1.96; RR 1.72, 95% CI 1.14-2.60, respectively). High ALR and the combined high ALR and low APOR were identified as risk factors for earlier time to first AFO. This study highlights the potential of ALR and APOR as makers for predicting the risk of future airflow obstruction.
先前的研究表明，脂联素/瘦素（ALR）和载脂蛋白 B/A1（APOR）比值与慢性阻塞性肺疾病（COPD）风险之间存在关联。本纵向观察性研究利用韩国基因组与流行病学研究（KoGES）的数据，根据 ALR 和 APOR 组，检查了肺功能下降的速度、气流阻塞（AFO）的危险因素以及首次 AFO 的时间。在 5578 名参与者中，高 ALR 和低 APOR 与肺功能快速下降和首次 AFO 时间缩短有关。高 ALR 组和高 ALR 与低 APOR 联合组均表现出更高的 AFO 风险，至少一次（RR 1.46，95%CI 1.12-1.90；RR 1.74，95%CI 1.23-2.46）和最终随访（RR 1.44，95%CI 1.05-1.96；RR 1.72，95%CI 1.14-2.60）。高 ALR 和高 ALR 与低 APOR 联合被确定为首次 AFO 时间提前的危险因素。这项研究强调了 ALR 和 APOR 作为预测未来气流阻塞风险的标志物的潜力。
