Wan-Zhe Liao, Nanshan College of Guangzhou Medical University, Guangzhou, China, E-mail:
J Prev Alzheimers Dis. 2024;11(2):445-452. doi: 10.14283/jpad.2024.31.
Alzheimer's disease (AD) is the leading cause of dementia in old age, recognized as a global health priority. To explore causal effects of fresh fruit intake and dried fruit intake on AD liability, this study utilized GWAS from the UK Biobank and FinnGen to conduct Mendelian randomization (MR) analysis, and used inverse variance weighted (IVW), MR-Egger, and weighted median approaches for MR estimates, and visual inspections judged result stability. Results suggested little evidence of a potential causal relationship between fresh fruit intake and AD (OR=0.97, 95%CI=0.50-1.91, P=0.939), while significant, robust causality was indicated between dried fruit intake and AD (OR=4.09, 95%CI=2.07-8.10, P<0.001). Stability evaluations showed no heterogeneity or pleiotropy affecting interpretability and credibility of primary analyses. In conclusion, we strengthened evidence for positive causality from dried fruit intake to AD liability, with causality from fresh fruit intake on AD risk was not demonstrated.
阿尔茨海默病（AD）是老年痴呆症的主要病因，被认为是全球卫生重点。为了探索新鲜水果摄入和干果摄入对 AD 易感性的因果关系，本研究利用英国生物银行和芬兰基因的 GWAS 进行孟德尔随机化（MR）分析，并使用逆方差加权（IVW）、MR-Egger 和加权中位数方法进行 MR 估计，并通过视觉检查判断结果稳定性。结果表明，新鲜水果摄入与 AD 之间几乎没有潜在的因果关系（OR=0.97，95%CI=0.50-1.91，P=0.939），而干果摄入与 AD 之间存在显著、稳健的因果关系（OR=4.09，95%CI=2.07-8.10，P<0.001）。稳定性评估表明，没有异质性或多效性影响主要分析的可解释性和可信度。总之，我们加强了干果摄入与 AD 易感性之间的因果关系证据，而新鲜水果摄入与 AD 风险之间的因果关系并未得到证实。
