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精准预防科学:减少心血管健康差异的研究机遇与临床应用

The Science of Precision Prevention: Research Opportunities and Clinical Applications to Reduce Cardiovascular Health Disparities.

作者信息

Pearson Thomas A, Vitalis Debbie, Pratt Charlotte, Campo Rebecca, Armoundas Antonis A, Au David, Beech Bettina, Brazhnik Olga, Chute Christopher G, Davidson Karina W, Diez-Roux Ana V, Fine Lawrence J, Gabriel Davera, Groenveld Peter, Hall Jaclyn, Hamilton Alison B, Hu Hui, Ji Heng, Kind Amy, Kraus William E, Krumholz Harlan, Mensah George A, Merchant Raina M, Mozaffarian Dariush, Murray David M, Neumark-Sztainer Dianne, Petersen Maya, Goff David

机构信息

College of Medicine and College of Public Health and Health Professions, University of Florida Health Science Center, Gainesville, Florida, USA.

Division of Cardiovascular Sciences, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA.

出版信息

JACC Adv. 2024 Jan;3(1). doi: 10.1016/j.jacadv.2023.100759. Epub 2023 Dec 13.

Abstract

Precision prevention embraces personalized prevention but includes broader factors such as social determinants of health to improve cardiovascular health. The quality, quantity, precision, and diversity of data relatable to individuals and communities continue to expand. New analytical methods can be applied to these data to create tools to attribute risk, which may allow a better understanding of cardiovascular health disparities. Interventions using these analytic tools should be evaluated to establish feasibility and efficacy for addressing cardiovascular disease disparities in diverse individuals and communities. Training in these approaches is important to create the next generation of scientists and practitioners in precision prevention. This state-of-the-art review is based on a workshop convened to identify current gaps in knowledge and methods used in precision prevention intervention research, discuss opportunities to expand trials of implementation science to close the health equity gaps, and expand the education and training of a diverse precision prevention workforce.

摘要

精准预防涵盖个性化预防,但还包括更广泛的因素,如健康的社会决定因素,以改善心血管健康。与个人和社区相关的数据在质量、数量、精准度和多样性方面都在不断扩展。新的分析方法可应用于这些数据,以创建风险归因工具,这可能有助于更好地理解心血管健康差异。应评估使用这些分析工具的干预措施,以确定其在解决不同个体和社区心血管疾病差异方面的可行性和有效性。开展这些方法的培训对于培养下一代精准预防领域的科学家和从业者至关重要。本前沿综述基于一次研讨会撰写,该研讨会旨在识别精准预防干预研究中当前在知识和方法上存在的差距,讨论扩大实施科学试验以缩小健康公平差距的机会,并扩大对多样化精准预防工作队伍的教育和培训。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3e89/11198059/f7f1bdfb1c9e/ga1.jpg

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