Sherzay Najia, Azimi Ziauddin, Sheikh Abdul Kadir Siti Hamimah, Mohd Nor Noor Shafina
Institute for Pathology, Laboratory and Forensic Medicine (I-PPerForM), Universiti Teknologi MARA, Cawangan Selangor, Sungai Buloh, Selangor, 47000, Malaysia.
Department of Biochemistry, Faculty of Pharmacy, Kabul University, Karte Sakhi, Kabul, Afghanistan.
J Blood Med. 2024 Feb 15;15:69-75. doi: 10.2147/JBM.S437594. eCollection 2024.
This study was designed and conducted to validate the reference values of hematological parameters for healthy adult male and female residents of Kabul city, Afghanistan.
In this cross-sectional study, the samples were collected according to a non-random sampling method. Blood samples were collected from students and employees of Kabul University. The study included 166 males and 125 females, aged 18-45 years. The selection and exclusion of participants were carried out according to a questionnaire and the assessment of serum ferritin and vitamin B levels. Candidates with lower serum ferritin and vitamin B, a history of chronic disease, females with menstruation or pregnancy, and those with chronic abdominal pain were excluded.
Reference ranges for all blood parameters were determined by a non-parametric method. The determined reference values were compared between males and females by the -test. Reference intervals for hemoglobin (4.5-6.3 g/dL for males and 3.66-5.67 g/dL for females) and hematocrit (36.23-55.93% for males and 30.20-53.86% for females) were significantly (<0.05) higher in males. No significant (<0.05) differences were observed between the reference intervals for the red blood cell count.
Therefore, we conclude that the commonly used reference intervals should be revised for the Afghan population, as our findings indicated higher reference values for the hemoglobin and hematocrit indices.
本研究旨在确定阿富汗喀布尔市健康成年男性和女性居民血液学参数的参考值并进行验证。
在这项横断面研究中，样本采用非随机抽样方法收集。从喀布尔大学的学生和员工中采集血样。该研究纳入了166名男性和125名女性，年龄在18至45岁之间。根据问卷以及血清铁蛋白和维生素B水平评估进行参与者的选择和排除。血清铁蛋白和维生素B水平较低者、有慢性病病史者、处于经期或孕期的女性以及有慢性腹痛者被排除。
所有血液参数的参考范围通过非参数方法确定。通过t检验比较男性和女性之间确定的参考值。男性的血红蛋白参考区间（4.5 - 6.3 g/dL）和血细胞比容参考区间（36.23 - 55.93%）显著高于女性（<0.05）。红细胞计数参考区间之间未观察到显著差异（<0.05）。
因此，我们得出结论，由于我们的研究结果表明血红蛋白和血细胞比容指数的参考值较高，所以应为阿富汗人群修订常用的参考区间。
