Design, synthesis and exploration of novel triazinoindoles as potent quorum-sensing inhibitors and radical quenchers.

Antimicrobial resistance has become a critical health concern, and quorum-sensing exacerbates the resistance by facilitating cell-to-cell communication within the microbial community, leading to severe pathogenic outbreaks. Novel 1-(2-((5-[1,2,4]-triazino[5,6-]indol-3-yl)thio)acetyl)indoline-2,3-diones were synthesized. The title compounds exhibit outstanding anti-quorum-sensing efficacy, and compound demonstrated the maximum proficiency (IC = 0.0504 μg/ml). The hybrids displayed potent antioxidant action, and compound showed the highest antioxidant ability (IC = 40.71 μg/ml). Molecular docking of the isatin hybrids against DNA gyrase and quorum-sensing receptor CviR validated the observed findings. The befitting pharmacokinetic profile of the synthesized drug candidates was ascertained through absorption, distribution, metabolism, excretion and toxicity screening. The remarkable biocompetence of the synthesized triazinoindoles may help to combat drug-resistant infections.