Institute of Sensor Technology, Easytem Co., Ltd., Seoul, Korea.
APR Co., Ltd., Seoul, Korea.
J Cosmet Dermatol. 2024 Jun;23(6):2240-2248. doi: 10.1111/jocd.16225. Epub 2024 Feb 20.
To increase skin permeability, various transdermal delivery techniques have been developed. However, due to the stratum corneum as a skin barrier, transdermal delivery remains limited.
In this study, we evaluated efficacy and safety of arc-poration as a novel technique disrupting the stratum corneum.
Optical images and histological analysis using reconstituted human skin and porcine skin showed that the treatment of arc-poration created micropores with an average diameter of approximately 100 μm only to the depth of the stratum corneum, but not viable epidermis. In addition, the Franz diffusion cell experiment using reconstituted human skin showed a remarkable increase in permeability following pretreatment with arc-poration. Clinical results clearly demonstrated the enhancement of the skin-improving effect of cosmetics by pretreatment of arc-poration in terms of gloss, hydration, flakiness, texture, tone, tone evenness, and pigmentation of skin, without causing abnormal skin responses. The concentration of ozone and nitrogen oxides generated by arc-poration was below the permissible value for the human body.
Arc-poration can increase skin permeability by creating stratum corneum-specific micropores, which can enhance the skin-improving effect of cosmetics without adverse responses.
为了提高皮肤的通透性，已经开发了各种透皮给药技术。然而，由于角质层是皮肤的屏障，透皮给药仍然受到限制。
本研究评估了弧形穿孔作为一种破坏角质层的新技术的疗效和安全性。
使用重建人皮肤和猪皮的光学图像和组织学分析表明，弧形穿孔处理仅在角质层深度形成平均直径约为 100μm 的微孔，而不会损伤活表皮。此外，使用重建人皮肤的 Franz 扩散池实验表明，弧形穿孔预处理后通透性显著增加。临床结果清楚地表明，弧形穿孔预处理可增强化妆品的皮肤改善效果，表现在皮肤的光泽度、水润度、剥落度、质地、肤色、肤色均匀度和色素沉着度方面，而不会引起异常的皮肤反应。弧形穿孔产生的臭氧和氮氧化物浓度低于人体允许值。
弧形穿孔可以通过形成角质层特异性的微孔来增加皮肤的通透性，从而增强化妆品的皮肤改善效果，而不会产生不良反应。
