Escobar-Chávez J J, Merino-Sanjuán V, López-Cervantes M, Urban-Morlan Z, Piñón-Segundo E, Quintanar-Guerrero D, Ganem-Quintanar A
Departamento de Farmacia y Tecnología Farmacéutica, Universidad de Valencia, Av. Vicente Andrés Estellés s/n, Burjassot, Valencia, España.
J Pharm Pharm Sci. 2008;11(1):104-30. doi: 10.18433/j3201z.
Quantification of drugs within the skin is essential for topical and transdermal delivery research. Over the last two decades, horizontal sectioning, consisting of tape stripping throughout the stratum corneum, has become one of the traditional investigative techniques. Tape stripping of human stratum corneum is widely used as a method for studying the kinetics and penetration depth of drugs. This paper shows the applications of the tape stripping technique to quantify drug penetration through the skin, underlining its versatile application in the area of topical and transdermal drugs.
对皮肤内药物进行定量分析对于局部给药和透皮给药研究至关重要。在过去二十年中，水平切片法，即通过在整个角质层进行胶带剥离，已成为传统的研究技术之一。人体角质层的胶带剥离被广泛用作研究药物动力学和渗透深度的方法。本文展示了胶带剥离技术在定量药物经皮渗透方面的应用，强调了其在局部和透皮药物领域的广泛应用。
