Center for Neural Science and Medicine, Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA.
Board of Governors Regenerative Medicine Institute, Cedars-Sinai Medical Center, Los Angeles, CA.
Diabetes. 2024 Mar 1;73(3):338-347. doi: 10.2337/db23-0706.
The recognition of sensory signals from within the body (interoceptive) and from the external environment (exteroceptive), along with the integration of these cues by the central nervous system, plays a crucial role in maintaining metabolic balance. This orchestration is vital for regulating processes related to both food intake and energy expenditure. Animal model studies indicate that manipulating specific populations of neurons in the central nervous system which influence these processes can effectively modify energy balance. This body of work presents an opportunity for the development of innovative weight loss therapies for the treatment of obesity and type 2 diabetes. In this overview, we delve into the sensory cues and the neuronal populations responsible for their integration, exploring their potential in the development of weight loss treatments for obesity and type 2 diabetes. This article is the first in a series of Perspectives that report on research funded by the American Diabetes Association Pathway to Stop Diabetes program.
体内感觉信号（内感受）和来自外部环境的感觉信号（外感受）的识别，以及中枢神经系统对这些线索的整合，在维持代谢平衡方面起着至关重要的作用。这种协调对于调节与食物摄入和能量消耗相关的过程至关重要。动物模型研究表明，操纵中枢神经系统中影响这些过程的特定神经元群体可以有效地改变能量平衡。这项工作为开发治疗肥胖症和 2 型糖尿病的创新减肥疗法提供了机会。在这篇综述中，我们深入探讨了负责整合这些感觉线索的感觉线索和神经元群体，探索了它们在肥胖症和 2 型糖尿病减肥治疗中的潜力。本文是美国糖尿病协会“停止糖尿病之路”计划资助的一系列观点报告中的第一篇。
