Department of Dermatology, Asan Medical Center, University of Ulsan College of Medicine, 88 Olympic-ro 43 gil, Songpa-gu, Seoul, 05505, Republic of Korea.
Asan Institute for Life Sciences, Asan Medical Center, Seoul, Republic of Korea.
Sci Rep. 2024 Feb 20;14(1):4212. doi: 10.1038/s41598-024-54407-z.
Although various comorbidities have been noted to be associated with atopic dermatitis (AD) and psoriasis, few studies have compared comorbidities between the two diseases, and little is known about whether these comorbidities vary by the subtypes of psoriasis. In this study of 1:1 age- and sex-matched pair analysis between patients diagnosed with either psoriasis or AD at Asan Medical Center between 1991 and 2020, comorbidities, as determined by the International Classification of Diseases-10 codes, and likelihood ratios of metabolic and neurologic comorbidities in psoriasis compared with AD were studied using a logistic regression model. Among a total of 14,128 patients, the psoriasis group had higher odds of obesity (odds ratio [95% confidence interval]: 1.49 [1.34-1.66]), hypertension (1.14 [1.03-1.26]), diabetes mellitus (1.46 [1.29-1.66]), chronic kidney disease (1.59 [1.22-2.08]), and Parkinson's disease (2.1 [1.15-3.83]) than the AD group. Subgroup analysis revealed that patients with plaque psoriasis had higher odds of obesity (1.18 [1.05-1.33]), hypertension (1.18 [1.06-1.32]), diabetes mellitus (1.53 [1.34-1.75]), chronic kidney disease (1.66 [1.26-2.17]), and Parkinson's disease (2.12 [1.16-3.88]) compared with AD. Meanwhile, guttate psoriasis was associated with higher odds of dementia (3.63 [1.06-12.40]) and patients with generalized pustular psoriasis showed higher odds of diabetes mellitus (5.42 [1.56-18.83]) compared with AD. In conclusion, Asian patients with all types of psoriasis should be closely monitored for the development of metabolic and neurologic diseases, especially men and those aged ≥ 40 years.
虽然已经注意到许多合并症与特应性皮炎 (AD) 和银屑病有关，但很少有研究比较这两种疾病的合并症，并且对于这些合并症是否因银屑病的亚型而异知之甚少。在这项研究中，我们对 1991 年至 2020 年期间在 Asan 医疗中心被诊断为银屑病或 AD 的患者进行了 1:1 年龄和性别匹配的配对分析，使用逻辑回归模型研究了国际疾病分类第 10 版 (ICD-10) 确定的合并症以及与 AD 相比，银屑病的代谢和神经合并症的可能性比。在总共 14128 名患者中，与 AD 组相比，银屑病组肥胖 (优势比 [95%置信区间]：1.49 [1.34-1.66])、高血压 (1.14 [1.03-1.26])、糖尿病 (1.46 [1.29-1.66])、慢性肾脏病 (1.59 [1.22-2.08]) 和帕金森病 (2.1 [1.15-3.83]) 的可能性更高。亚组分析显示，斑块状银屑病患者肥胖的可能性更高 (1.18 [1.05-1.33])、高血压 (1.18 [1.06-1.32])、糖尿病 (1.53 [1.34-1.75])、慢性肾脏病 (1.66 [1.26-2.17]) 和帕金森病 (2.12 [1.16-3.88]) 比 AD 高。与此同时，点滴状银屑病与痴呆的可能性更高相关 (3.63 [1.06-12.40])，泛发性脓疱型银屑病患者发生糖尿病的可能性更高 (5.42 [1.56-18.83]) 与 AD 相比。总之，亚洲所有类型的银屑病患者都应该密切监测代谢和神经疾病的发生，尤其是男性和年龄≥40 岁的患者。
