黏连蛋白的调控及其在染色体结构和功能中的作用。
Cohesin regulation and roles in chromosome structure and function.
机构信息
Curriculum in Genetics & Molecular Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Department of Biophysics & Biochemistry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA; Department of Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA; Integrative Program for Biological and Genome Sciences, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
出版信息
Curr Opin Genet Dev. 2024 Apr;85:102159. doi: 10.1016/j.gde.2024.102159. Epub 2024 Feb 20.
Chromosome structure regulates DNA-templated processes such as transcription of genes. Dynamic changes to chromosome structure occur during development and in disease contexts. The cohesin complex is a molecular motor that regulates chromosome structure by generating DNA loops that bring two distal genomic sites into close spatial proximity. There are many open questions regarding the formation and dissolution of DNA loops, as well as the role(s) of DNA loops in regulating transcription of the interphase genome. This review focuses on recent discoveries that provide molecular insights into the role of cohesin and chromosome structure in gene transcription during development and disease.
染色体结构调控 DNA 模板的过程，如基因转录。在发育和疾病环境中，染色体结构会发生动态变化。黏合蛋白复合物是一种分子马达，通过生成 DNA 环来调节染色体结构，使两个远端基因组位点在空间上接近。关于 DNA 环的形成和溶解，以及 DNA 环在调节间期基因组转录中的作用，仍存在许多悬而未决的问题。这篇综述重点介绍了最近的发现，这些发现为黏合蛋白和染色体结构在发育和疾病过程中基因转录中的作用提供了分子见解。
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