Farrell E M, Higginson L A, Nip W S, Walley V M, Keon W J
J Vasc Surg. 1986 Feb;3(2):284-7. doi: 10.1067/mva.1986.avs0030284.
Laser angioplasty has been limited by the lack of precise control of thermal and acoustic vascular injury. Pulsed excimer lasers, by contrast, have a capacity to affect target tissue without heat dispersion or damage to surrounding structures. The ablative properties of three excimer wavelengths, krypton fluoride (249 nm), xenon chloride (308 nm), and xenon fluoride (351 nm), were investigated with the use of fresh human cadaveric normal and atherosclerotic femoral arteries. Light and electron microscopy demonstrated clean cuts with histologically normal edges. There was no evidence of either thermal or acoustic damage with any of the wavelengths studied. The depth of ablation varied directly with the number of pulses and inversely with tissue density while the incision width remained constant. The excimer laser appears to offer significant advantages over its conventional counterparts for the ablation of atherosclerotic plaque.
激光血管成形术一直受到热和声学血管损伤缺乏精确控制的限制。相比之下，脉冲准分子激光有能力在不产生热扩散或不损伤周围结构的情况下作用于目标组织。使用新鲜的人体尸体正常和动脉粥样硬化股动脉，研究了三种准分子波长，即氟化氪（249纳米）、氯化氙（308纳米）和氟化氙（351纳米）的消融特性。光学显微镜和电子显微镜显示切口干净，边缘组织学正常。在所研究的任何波长下，均没有热损伤或声学损伤的证据。消融深度与脉冲数成正比，与组织密度成反比，而切口宽度保持不变。对于动脉粥样硬化斑块的消融，准分子激光似乎比传统的同类激光具有显著优势。
