低剂量¹³¹I治疗Graves病
Low-dose 131I in treatment of Graves' disease.
作者信息
Lowdell C P, Dobbs H J, Spathis G S, McCready V R, Cosgrove D O, Harmer C L
出版信息
J R Soc Med. 1985 Mar;78(3):197-202. doi: 10.1177/014107688507800305.
Abstract
One hundred and sixty-four patients with Graves' disease were treated with low-dose radioiodine (2 mCi), with a mean follow up of 4 1/2 years. At this time 74 (45%) were euthyroid having had a single dose, with a total of 131 (80%) being controlled with one or more doses. Three (2%) were still toxic but their mean follow up was only 3 years. Thirty (18%) were rendered hypothyroid, two-thirds of these after a single dose of 2 mCi 131I. The one-year incidence of hypothyroidism was 6%, with an incidence at 6 years of 20%. Previous surgery, medical treatment and thyroid antibody status appeared to have no influence on the outcome.
摘要
164例格雷夫斯病患者接受了低剂量放射性碘（2毫居里）治疗，平均随访4.5年。此时，74例（45%）单次给药后甲状腺功能正常，131例（80%）经一次或多次给药后病情得到控制。3例（2%）仍有甲状腺毒症，但平均随访时间仅为3年。30例（18%）出现甲状腺功能减退，其中三分之二是在单次服用2毫居里131I后出现的。甲状腺功能减退的一年发病率为6%，6年发病率为20%。既往手术、药物治疗和甲状腺抗体状态似乎对治疗结果没有影响。
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