San Marco J L, Tobiana F, Dupin B, Simonin R
Ann Endocrinol (Paris). 1980 Nov-Dec;41(6):597-600.
277 patients treated by radio iodine for Graves' disease were observed during a one to twenty three years period. 24 % relapse, always during the first three years. Hypothyroidism is ineluctable : 20 % from the first year and 3,4 % more each year. Goiter increases the delay for hypothyroidism occurrence. There is no linkage between hypothyroidism and radio iodine dose. Radio iodine does not cure graves' disease but give a "non hypo-non hyper" status, before secondary hypothyroidism.
对277例接受放射性碘治疗的格雷夫斯病患者进行了为期1至23年的观察。24%的患者复发，且均在头三年复发。甲状腺功能减退不可避免：第一年为20%，之后每年增加3.4%。甲状腺肿会延长甲状腺功能减退发生的时间。甲状腺功能减退与放射性碘剂量之间没有关联。放射性碘并不能治愈格雷夫斯病，而是在继发性甲状腺功能减退之前给予一种“非甲减非甲亢”的状态。
