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The cycad genotoxin methylazoxymethanol, linked to Guam ALS/PDC, induces transcriptional mutagenesis.

作者信息

Verheijen Bert M, Chung Claire, Thompson Ben, Kim Hyunjin, Nakahara Asa, Anink Jasper J, Mills James D, Lee Jeong H, Aronica Eleonora, Oyanagi Kiyomitsu, Kakita Akiyoshi, Gout Jean-Francois, Vermulst Marc

机构信息

School of Gerontology, University of Southern California, Los Angeles, CA, 90089, USA.

Department of Neuroscience, Maastricht University, Maastricht, The Netherlands.

出版信息

Acta Neuropathol Commun. 2024 Feb 21;12(1):30. doi: 10.1186/s40478-024-01725-y.

DOI:10.1186/s40478-024-01725-y
PMID:38383591
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10882831/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2184/10882831/43a58937ba81/40478_2024_1725_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2184/10882831/55e8a25f248c/40478_2024_1725_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2184/10882831/43a58937ba81/40478_2024_1725_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2184/10882831/55e8a25f248c/40478_2024_1725_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2184/10882831/43a58937ba81/40478_2024_1725_Fig2_HTML.jpg

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Nucleic Acids Res. 2024 Sep 9;52(16):e76. doi: 10.1093/nar/gkae632.
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Tau filaments from amyotrophic lateral sclerosis/parkinsonism-dementia complex adopt the CTE fold.来自肌萎缩侧索硬化症/帕金森病痴呆复合征的 tau 丝采用 CTE 折叠。
Proc Natl Acad Sci U S A. 2023 Dec 19;120(51):e2306767120. doi: 10.1073/pnas.2306767120. Epub 2023 Dec 15.
3
Transcriptional mutagenesis of α-synuclein caused by DNA oxidation in Parkinson's disease pathogenesis.
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Nat Commun. 2024 Oct 7;15(1):8676. doi: 10.1038/s41467-024-52886-2.
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Introducing the Role of Genotoxicity in Neurodegenerative Diseases and Neuropsychiatric Disorders.介绍遗传毒性在神经退行性疾病和神经精神障碍中的作用。
Int J Mol Sci. 2024 Jun 29;25(13):7221. doi: 10.3390/ijms25137221.
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Novel Techniques for Mapping DNA Damage and Repair in the Brain.新型技术可绘制大脑中的 DNA 损伤与修复图谱
Int J Mol Sci. 2024 Jun 27;25(13):7021. doi: 10.3390/ijms25137021.
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