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Deposition of mutant ubiquitin in parkinsonism-dementia complex of Guam.

作者信息

Verheijen Bert M, Hashimoto Tomoyo, Oyanagi Kiyomitsu, van Leeuwen Fred W

机构信息

Department of Translational Neuroscience, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, The Netherlands.

Department of Neurology and Neurosurgery, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, The Netherlands.

出版信息

Acta Neuropathol Commun. 2017 Nov 9;5(1):82. doi: 10.1186/s40478-017-0490-0.

DOI:10.1186/s40478-017-0490-0
PMID:29122008
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5679492/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8d4f/5679492/f2c957a5b56c/40478_2017_490_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8d4f/5679492/f2c957a5b56c/40478_2017_490_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8d4f/5679492/f2c957a5b56c/40478_2017_490_Fig1_HTML.jpg

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本文引用的文献

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Long-term proteasomal inhibition in transgenic mice by UBB(+1) expression results in dysfunction of central respiration control reminiscent of brainstem neuropathology in Alzheimer patients.UBB(+1)表达导致转基因小鼠长期蛋白酶体抑制，导致中枢呼吸控制功能障碍，类似于阿尔茨海默病患者的脑干神经病理学。
Acta Neuropathol. 2012 Aug;124(2):187-97. doi: 10.1007/s00401-012-1003-7. Epub 2012 Jun 23.
2
Mutant ubiquitin (UBB+1) associated with neurodegenerative disorders is hydrolyzed by ubiquitin C-terminal hydrolase L3 (UCH-L3).与神经退行性疾病相关的突变泛素（UBB+1）可被泛素 C 端水解酶 L3（UCH-L3）水解。
FEBS Lett. 2011 Aug 19;585(16):2568-74. doi: 10.1016/j.febslet.2011.06.037. Epub 2011 Jul 6.
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Acta Neuropathol Commun. 2024 Feb 21;12(1):30. doi: 10.1186/s40478-024-01725-y.
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The fidelity of transcription in human cells.人类细胞中的转录保真度。
Proc Natl Acad Sci U S A. 2023 Jan 31;120(5):e2210038120. doi: 10.1073/pnas.2210038120. Epub 2023 Jan 25.
5
The Dose-Dependent Pleiotropic Effects of the UBB Ubiquitin Mutant.UBB泛素突变体的剂量依赖性多效性效应
Front Mol Biosci. 2021 Mar 26;8:650730. doi: 10.3389/fmolb.2021.650730. eCollection 2021.
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J Neuropathol Exp Neurol. 2021 Feb 22;80(3):286-288. doi: 10.1093/jnen/nlab006.
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Front Neurol. 2018 Mar 20;9:173. doi: 10.3389/fneur.2018.00173. eCollection 2018.
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6
TDP-43 is deposited in the Guam parkinsonism-dementia complex brains.TDP-43沉积于关岛帕金森痴呆综合征患者的大脑中。
Brain. 2007 May;130(Pt 5):1386-94. doi: 10.1093/brain/awm065. Epub 2007 Apr 17.
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Parkinsonism-dementia complex of Guam.关岛帕金森痴呆综合征
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Hum Mol Genet. 2004 Aug 15;13(16):1803-13. doi: 10.1093/hmg/ddh188. Epub 2004 Jun 15.
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Disease-specific accumulation of mutant ubiquitin as a marker for proteasomal dysfunction in the brain.突变泛素的疾病特异性积累作为大脑中蛋白酶体功能障碍的标志物。
FASEB J. 2003 Nov;17(14):2014-24. doi: 10.1096/fj.03-0205com.
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Brain. 1961 Dec;84:662-79. doi: 10.1093/brain/84.4.662.