Kim Tae-Un, Lee Seoung-Woo, Baek Su-Min, Yim Jae-Hyuk, Lee Young-Jin, Son Jun-Hyeok, Park Sang-Joon, Park Jin-Kyu
Department of Veterinary Pathology, College of Veterinary Medicine, Kyungpook National University, Daegu, Republic of Korea.
Laboratory of Veterinary Histology, College of Veterinary Medicine, Kyungpook National University, Daegu, Republic of Korea.
Vet Med (Praha). 2023 Jan 5;68(1):33-37. doi: 10.17221/77/2022-VETMED. eCollection 2023 Jan.
Apocrine cystomatosis, also called epitrichial sweat gland cystomatosis, is a non-neoplastic condition characterised by multiple dilated cysts of sweat gland origin. Histopathologically, these cysts comprise two layers of cells: an inner layer of glandular epithelial cells and an outer layer of myoepithelial cells. A case of apocrine cystomatosis was admitted to a local hospital. The microscopic investigation revealed that some enlarged cysts showed the transition of glandular epithelial cells into a spindle, mesenchymal cell-like morphology. The epithelial-to-mesenchymal transition (EMT) has long been studied as a pathway for embryogenesis, organ development, and carcinogenesis. While various molecular factors, including cytokines and growth factors, are known to induce EMT, mechanical forces have also been proposed to initiate EMT. The present case describes a possible relationship between EMT occurring in a cystic condition and further pathological inspection.
顶泌汗腺囊瘤病，也称为毛囊汗腺囊瘤病，是一种非肿瘤性疾病，其特征为多个起源于汗腺的扩张囊肿。组织病理学上，这些囊肿由两层细胞组成：一层为腺上皮细胞，另一层为肌上皮细胞。一名顶泌汗腺囊瘤病患者入住当地医院。显微镜检查发现，一些增大的囊肿显示腺上皮细胞转变为梭形、间充质细胞样形态。上皮-间质转化（EMT）长期以来一直被作为胚胎发生、器官发育和肿瘤发生的一种途径进行研究。虽然已知包括细胞因子和生长因子在内的多种分子因素可诱导EMT，但也有人提出机械力可启动EMT。本病例描述了囊性病变中发生的EMT与进一步病理检查之间的可能关系。
