Sharan M, Singh M P
Int J Biomed Comput. 1985 Jan;16(1):59-80. doi: 10.1016/0020-7101(85)90045-5.
The process of gas exchange leading to the oxygenation of blood in pulmonary capillaries is simulated numerically, taking into account the main transport mechanisms of molecular diffusion, convection and the facilitated diffusion due to the presence of haemoglobin, as well as physiologically relevant boundary conditions and variable initial data. An algorithmic program to solve the relevant equations is run on a computer. It is found that, in the immediate neighbourhood of the entry, the amount of dissolved oxygen decreases, whereas the amount of carbaminohaemoglobin increases and the facilitated diffusion is more dominant over the molecular diffusion. Further, it is shown that (i) O2 takes longest and CO2 is the fastest to attain equilibration, (ii) the blood is completely oxygenated with one fifth part of its transit. Finally, the effect of various physiological parameters on equilibration length is examined.
对肺毛细血管中导致血液氧合的气体交换过程进行了数值模拟，考虑了分子扩散、对流以及由于血红蛋白存在而产生的易化扩散等主要传输机制，以及生理相关的边界条件和可变的初始数据。在计算机上运行一个求解相关方程的算法程序。结果发现，在入口的紧邻区域，溶解氧的量减少，而氨基甲酰血红蛋白的量增加，并且易化扩散比分子扩散更占主导。此外，结果表明：（i）氧气达到平衡所需时间最长，二氧化碳达到平衡最快；（ii）血液在其行程的五分之一时就完全被氧合。最后，研究了各种生理参数对平衡长度的影响。
