Sharan M, Aminataei A, Singh M P
Centre for Atmospheric and Fluids Sciences, Indian Institute of Technology, Delhi.
J Math Biol. 1987;25(4):433-52. doi: 10.1007/BF00277167.
A mathematical model is formulated for simulating the unsteady transport of gases in the blood flowing through the pulmonary capillaries. The formulation takes into account the transport mechanisms of molecular diffusion, convection and facilitated diffusion of the species due to haemoglobin. A time dependent situation is created by allowing to vary suddenly the partial pressures of the gases either in the venous blood or in the alveolar air. A numerical technique is described to solve the resulting time-dependent system of nonlinear coupled partial differential equations with the physiologically relevant boundary, entrance and initial conditions. The time required by the gases to achieve equilibrium is computed. It is shown that the dissolved oxygen takes longest in reaching equilibration whereas the carbon dioxide is the fastest. The various physiologically relevant unsteady situations have been examined.
